Arun, R (2015) Study of Cognitive Function and Recovery after low Flow Sevoflurane Anesthesia in patients undergoing Elective Laparoscopic Cholecystectomy Surgeries a comparison of Low Flow and Medium-Flow Anesthesia: A Study of 60 cases. Masters thesis, Madurai Medical College, Madurai.
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Abstract
AIM OF THE STUDY: The aim of the study is to compare the effects of medium flow and low flow Sevoflurane Anesthesia on post operative Cognitive function and recovery in patients undergoing Elective Laparoscopic Cholecystectomy Surgeries. MATERIALS AND METHODS: 60 ASA 1 and 2 patients aged 25 to 60 years undergoing Elective Laparoscopic Cholecystectomy Surgeries were selected. They were randomly divided into two groups low flow group and medium flow group. The General Anesthesia was standardized for two groups. During maintenance the fresh gas flow was set to 11/min in low flow group and 41/min in medium flow group. The Sevoflurane concentration was set to 2%. The MMSE score, VAS score and Ramsey sedation score recorded preoperatively, at 1 hr, 3 hrs, 6 hrs and 4 hrs post operatively. RESULTS: There were no significant differences in recovery times or MMSE scores between the groups. 4 (13.3%) patients in the low flow group and 3 (10%) patients in the medium flow group had decrease in the first hour MMSE score more than 2 when compared to baseline score which was defined as cognitive dysfunction. Emergence recovery criteria (ie) the time taken to open eyes, squeeze fingers, extubation, recalling name and the time taken for aldrete score > 9 also had no significant differences the low flow and the medium flow group. The fresh gas flow have no effect over the post operative cognitive dysfunction and recovery. DISCUSSION: The effect of Sevoflurane on post operative cognitive dysfunction is not clear. The production of compound A have led to the controversies in the safety of low flow Sevoflurane anesthesia. The effect of low flow Sevoflurane anesthesia on recovery and post operative cognitive dysfunction is not clear. The MMSE score was used to determine the cognitive dysfunction. The reduction in the score > 2 post operatively was the criteria to determine cognitive dysfunction. Our study did not find a significant difference in recovery and post operative cognitive dysfunction. CONCLUSION: We conclude that the fresh gas flow have no effect on the post operative cognitive dysfunction and recovery times in patients undergoing sevoflurane anesthesia for elective laparoscopic cholecystectomy surgeries.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Sevoflurane, MMSE score, General Anaesthesia. |
| Subjects: | MEDICAL > Anaesthesiology |
| Depositing User: | Punitha K |
| Date Deposited: | 07 May 2018 04:00 |
| Last Modified: | 08 May 2018 06:20 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/7575 |
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