Reena Sanges, V (2015) A Prospective, Randomized Placebo Controlled study Evaluating the Effectiveness of Oral Pregabalin and Tramadol for Postoperative Pain Management in Patients Undergoing Lumbar. Masters thesis, Madras Medical College, Chennai.
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Abstract
Postoperative pain is one of the most feared problems among patients coming for surgery. Preventing and treating postoperative pain is a big deal despite recent advances in pain therapy. Opioids continue to be a cornerstone in the treatment of postoperative pain inspite of their side effects. Pregabalin, a structural analog of gamma-aminobutyric acid, has been used for the treatment of neuropathic pain and as an adjuvant in treating partial seizures. This study was thus taken up to compare the analgesic and anxiolytic effects of pregabalin and tramadol by administering it preoperatively in patients undergoing elective decompressive lumbar laminectomy. The study was conducted in 75 patients belonging to ASA 1 & 2 between 20 to 60 years. These patients were randomly allocated into three groups- group 1, 2 & 3 containing 25 patients each. Group 1, 2 & 3 received placebo capsule, 100mg tramadol capsule and 150 mg pregabalin capsule respectively 1 hour before anaesthetic induction. Pregabalin showed stastistically significant analgesic and anxiolytic effect when compared to placebo but less than that of tramadol. Also, pregabalin was associated with less sedation than that of tramadol. Postoperative complications like nausea, vomiting, drowsiness was less in pregabalin group compared to placebo group. Also, pregabalin provided a stable hemodynamics throughout the intraoperative period and also prevented the pressor response to laryngoscopy and intubation similar to tramadol. The result of this study support the use of pregabalin for postoperative pain relief as it has fewer side effects, well tolerated and higher patient satisfaction.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Pregabalin ; Tramadol ; postoperative pain ; lumbar laminectomy. |
| Subjects: | MEDICAL > Anaesthesiology |
| Depositing User: | Punitha K |
| Date Deposited: | 07 May 2018 03:16 |
| Last Modified: | 07 May 2018 03:16 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/7562 |
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