Chinmai, Jagadish (2015) Serum Growth Differentiation Factor 15 in Patients with Ulcerative Colitis. Masters thesis, Christian Medical College, Vellore.
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Abstract
BACKGROUND: Hepcidin is the central regulator of iron homeostasis. Previous work done in the Department of Biochemistry, CMC, Vellore, has shown that serum hepcidin levels were decreased in patients with ulcerative colitis. Growth differentiation factor-15 (GDF-15) is a known negative regulator of hepcidin. AIM OF THE STUDY: The aim of the study was to test the hypothesis that serum GDF-15 levels may be increased in patients with ulcerative colitis (UC), thus accounting for decreased levels of hepcidin in such patients and to determine whether it correlates with hemoglobin and markers of iron status (serum iron and ferritin). MATERIALS AND METHODS: Twenty patients diagnosed with UC, who were not on iron supplements or erythropoietin therapy, served as cases. Twenty age and gender-matched non-anaemic patients, who underwent upper gastrointestinal endoscopy for evaluation of dyspepsia and who were found to have no endoscopic abnormalities served as controls. A blood sample collected from each subject, after obtaining informed consent, was used to estimate haematological parameters and serum levels of GDF-15, iron, ferritin, and C-reactive protein (CRP). RESULTS: Serum GDF-15 levels were significantly higher (912.8 ± 430 pg/ml vs 623.7 ± 285 pg/ml) and hemoglobin levels significantly lower in patients with UC, when compared to control subjects. Levels of GDF-15 and haemoglobin showed a negative correlation with one another. CONCLUSION: Serum GDF-15 levels were increased in patients with UC. Such raised levels may account for decreased hepcidin levels that have been observed in such patients.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | GDF-15 ; ulcerative colitis ; anaemia ; iron ; hepcidin. |
| Subjects: | MEDICAL > Biochemistry |
| Depositing User: | Punitha K |
| Date Deposited: | 06 May 2018 15:26 |
| Last Modified: | 06 May 2018 15:26 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/7552 |
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