Karthiga, M (2015) Serum Prolactin Levels in Patients with Recently Diagnosed Rheumatoid Arthritis. Masters thesis, Madras Medical College, Chennai.
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Abstract
OBJECTIVES: The role of Prolactin in autoimmune diseases & use of anti Prolactin drugs in disease remission has been described & investigated in several studies. The role of antiprolactin drugs in remission of disease activity have been investigated. The present study was carried out to correlate serum Prolactin levels with disease severity in recently diagnosed Rheumatoid Arthritis patients. MATERIALS and METHODS: A case-control study was carried out in 55 recently diagnosed untreated Rheumatoid factor positive & RF negative Rheumatoid Arthritis patients and 27 age & sex matched apparently healthy individuals. The diagnosis of RA was made using ACR criteria 2010. Serum Prolactin(ELISA), serum Anti CCP (ELISA), RF (Latex agglutination method), TSH(ELISA), ESR (conventional Westergrens method), Serum urea & creatinine were assayed. Disease severity was assessed by DAS (28) formula. Statistical evaluation was done by independent t-test,ANOVA, Pearson correlation coefficient. RESULTS: Serum Prolactin levels in RA patients was significantly higher (33.53±17.9ng/mL) compoared to controls (14.4±5.9) with p value of ˂ 0.001 . A fair correlation was found between disease activity and serum Prolactin levels ( r = 0.345 ; p = 0.01 ). CONCLUSION: Elevated levels of serum prolactin indicates the immunomodulatory role of PRL and its relationship to diseases activity. Use of Anti Prolactin drugs may be of use in patients with hyperprolactinemia.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Prolactin ; autoimmune disease ; rheumatoid arthritis. |
| Subjects: | MEDICAL > Biochemistry |
| Depositing User: | Punitha K |
| Date Deposited: | 06 May 2018 15:07 |
| Last Modified: | 06 May 2018 15:07 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/7549 |
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