Chezhian, J (2011) Correlation of Agatston Score in Patients with Obstructive and Nonobstructive Coronary Artery Disease Following Stemi. Masters thesis, Madras Medical College, Chennai.
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Abstract
Coronary artery calcification (CAC) is noticed in the early atherosclerotic lesions that appear in the second and third decades of life, but it is more often found in the advanced atherosclerotic lesions and in older age. Coronary arterial calcification is a change occurring almost exclusively in atherosclerotic arteries, and is absent in the normal vessel wall. Hence the presence of any CAC is nearly 100% specific for atheromatous coronary plaque. Since both obstructive and nonobstructive lesions can have calcification present in the intima, CAC is not specific for obstructive coronary disease. The site and the amount of coronary artery calcium and the percent of coronary luminal narrowing at the same anatomic site, the relation is nonlinear and has large confidence limits. As the occurrence of calcification reflects an advanced stage of plaque development, some researchers have proposed that the correlation between coronary calcification and acute coronary events may be suboptimal based largely on angiographic series. In order to understand this apparent conflict between the stability of a calcified lesion and CHD event rates, one must recognize the association between atherosclerotic plaque extent and more frequent calcified and non-calcified plaque. That is, patients who have calcified plaque are also more likely to have non-calcified or "soft" plaque that is prone to rupture and acute coronary thrombosis. CONCLUSION : 1) Sixty four slice MDCT derived Agatston score is a useful tool to assess angiographic severity in Post MI population. 2) Agatston score shows poor correlation in differentiating the obstructive and nonobstructive coronary artery disease following STEMI. 3) Agatston scores showed good correlation in patients with obstructive CAD especially in Elderly, Diabetics and in those with a family history of CAD. 4) There is less correlation of Agatston score with regards to other conventional risk factors like Gender, Hypertension and Smoking in both obstructive and non obstructive CAD. 5) Agatston score was not useful to identity infarct related artery. 6) There was no linear correlation between Agatston score and the number of vessel involvement. 7) There was a significant negative correlation in hypertensive patients among non obstructive CAD population.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Correlation ; Agatston Score Patients ; Obstructive Nonobstructive ; Coronary Artery ; Disease Following Stemi. |
| Subjects: | MEDICAL > Radio Diagnosis |
| Depositing User: | Subramani R |
| Date Deposited: | 30 Jun 2017 15:19 |
| Last Modified: | 30 Jun 2017 15:19 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/752 |
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