Comprehensive Analysis of 20 Cases of Systemic Sclerosis

Anbumalar, M (2015) Comprehensive Analysis of 20 Cases of Systemic Sclerosis. Masters thesis, Madurai Medical College, Madurai.


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AIM OF THE STUDY: To study the epidemiological features, occupational risk factors and skin and systemic manifestations of Systemic sclerosis. METHODS: 20 Patients who presented to the outpatient department fulfilling ARA criteria for Systemic sclerosis were enrolled. A detailed history and thorough examination was done. Investigations including complete blood count, ESR, renal function tests, blood sugar, liver function tests, urine routine, X-ray chest PA view, HRCT – chest, Pulmonary function test, ultrasound of abdomen and pelvis, ECG, ECHO cardiogram, Barium Swallow, upper GI scopy, X ray of both hands were done for all the cases. RESULTS: Female to male ratio was 5.7:1. 95% of cases were in the age group 21 -60 years. Occupational exposure to silica, solvents, pesticides and firework were present in 11 cases. Skin tightness (100%), Raynaud’s phenomenon (65%), stellate scars (90%), Round finger pad sign (85%), gangrene (10%),nek sign (80%), salt and pepper pigmentation (95%), generalized hyperpigmentation (45%), nail changes (70%) were noted. One case of mixed connective tissue disease and one case with overlap of Epidermolysis Bullosa Acquisita were recorded. Systemic involvement, gastroesophageal reflux (85%), Interstitial lung disease (95%), pulmonary arterial hypertension (5%), acral osteolysis (75%) was present. CONCLUSION: Female preponderance was noted. Occupational exposure was present in more than half of the patients. Even though skin involvement was present in all cases, 20% of cases presented only after systemic involvement. All the patients had diffuse involvement of skin. Only 65% patients had Raynaud’s phenomenon, this is probably because of higher temperature present throughout the year in South India. Systemic involvement was seen in most cases, mainly involving the pulmonary, gastrointestinal system. Interstitial lung disease was present in 95% cases. No patient had renal involvement.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Systemic Sclerosis ; Comprehensive Analysis ; 20 Cases.
Subjects: MEDICAL > Dermatology Venereology and Leprosy
Depositing User: Punitha K
Date Deposited: 05 May 2018 09:04
Last Modified: 05 May 2018 09:04

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