The Efficacy of Low-Molecular Weight Heparin in the Management of Generalized Cutaneous Lichen Planus

Sudhakar, N (2015) The Efficacy of Low-Molecular Weight Heparin in the Management of Generalized Cutaneous Lichen Planus. Masters thesis, Stanley Medical College, Chennai.

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Abstract

BACKGROUND AND OBJECTIVES: To assess the efficacy of low molecular weight heparin in the management of generalized cutaneous lichen planus. MATERIALS AND METHODS: This is a one year open label prospective randomized study from July 2013 to June 2014. About 50 cases of generalized Cutaneous lichen planus willing to participate and follow up were included in the study. A brief and relevant medical history was taken during the initial visit and physical examination done to ensure that all relevant eligible criteria are met. Patients were given Injection Enoxaparin sodium 4 mg SC once weekly for 9 weeks and later followed up for 6 months. Efficacy is assessed by monitoring Itch severity score (ISS), DLQI, and nature of old and new lesions. RESULTS: Clinical improvement noticed in the form of decrease in ISS with regression of cutaneous lesions within 1 to 3 weeks in 80 to 90% of cases. There was no occurrence of new lesions in 76% of cases. Improvement in DLQI was noticed in 80% and complete disappearance of itch in 66% of the patients at the end of the study. No adverse effects were observed. CONCLUSION: The rapid improvement and sustained remission in these cases implies that low molecular weight heparin could be a safe, effective and alternative monotherapy in the management of generalized cutaneous lichen planus.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Lichen planus ; Enoxaparin sodium ; ISS ; DLQI.
Subjects: MEDICAL > Dermatology Venereology and Leprosy
Depositing User: Punitha K
Date Deposited: 05 May 2018 08:45
Last Modified: 05 May 2018 08:45
URI: http://repository-tnmgrmu.ac.in/id/eprint/7484

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