Efficacy And Safety of Platelet Rich Plasma (PRP) for treatment of Acne Scars

Shubhra, Shukla (2015) Efficacy And Safety of Platelet Rich Plasma (PRP) for treatment of Acne Scars. Masters thesis, Stanley Medical College, Chennai.


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INTRODUCTION: Acne scarring can produce severe disfigurement of face. Scarring is a complex biological process that involves various chemical mediators, extracellular matrix, parenchymal resident cells and infiltrating blood cells. Autologous PRP has been found to stimulate fibroblast growth and therefore helps in scar healing. Modern technology allows us to concentrate platelets and white blood cells from a patient’s blood (autologous therapy) and to induce the release of growth factors by injecting the solution directly into injured tissue, stimulating the same healing process but in a more directed form. METHODS AND MATERIALS: Forty patients of atrophic acne scars attending Dermatology OPD in Govt. Stanley Hospital during period from June 2013 to May 2014 were selected. After brief & relevant medical history and physical examination, acne scars were graded. Informed consent and digital photographs of face were taken. PRP was injected by multiple tiny punctures under the dermis under topical anesthesia. Up to 6 sittings, 4 weeks apart were given within a 6-month time frame. At the end of treatment duration, scars were graded using grading system as used in the beginning, photographs taken and compared. OBSERVATIONS: Marked improvement was seen in 42.5 % patients while 35% patients showed moderate improvement. In maximum patients improvement became visible at the end of 3rd sitting. Patient satisfaction was good in 52.5% patients and very good in 27.5 % cases. There was a good reduction in DLQI too (61.13 % improvement). Complications seen were only in form of transient erythema and pain. CONCLUSION: Marked to Moderate improvement was seen in most cases, which is comparable with other modalities used for management of acne scars. It does not hamper daily activity of the patient as it is performed as out-patient procedure. To conclude Platelet rich plasma therapy is easy to perform and provides satisfactory results and that too with minimum side effects.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Acne scars ; Platelet rich Plasma.
Subjects: MEDICAL > Dermatology Venereology and Leprosy
Depositing User: Punitha K
Date Deposited: 05 May 2018 08:34
Last Modified: 05 May 2018 08:34
URI: http://repository-tnmgrmu.ac.in/id/eprint/7482

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