Study of Association between Lichen Planus and Hepatitis C Virus Infection

Nishant, Gupta (2015) Study of Association between Lichen Planus and Hepatitis C Virus Infection. Masters thesis, Stanley Medical College, Chennai.


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INTRODUCTION: Lichen planus is an immunologically mediated skin and mucous membrane disease, which can affect oral mucosa, the skin, genitalia, hair follicles, nails, esophagus, urinary tract, nasal mucosa, larynx and even the eyes. Lichen planus has been found in patients with Hepatitis C virus related liver disease, with variable frequency in several studies till date. However an association between HCV infection and lichen planus is uncertain because prevalence of HCV infection in patients with lichen planus varies considerably from one geographic area to another. If there is a true association, lichen planus in certain populations may be used as a sign of HCV infection in asymptomatic patients, leading to early diagnosis and treatment, and a better prognosis of infected patients. AIM AND OBJECTIVE: To study the association between Lichen planus and Hepatitis C infection in this geographical region. MATERIALS AND METHODS: Place: Govt. Stanley Medical College, Chennai. Type: Prospective, Observational TIME: July 2013 to June 2014. Sample SizE: 100 lichen planus patients, 100 controls. EXCLUSION CRITERIA: 1. Patients taking drugs causing lichenoid eruptions like beta- blockers, anti-malarials, diuretics, ACE inhibitors, chlorpropamide, simvastatin. 2. Pregnant/Lactating woman, 3. Pre-existing liver disease, 4. Past history of blood transfusion, 5. Intravenous drug users, 6. Blood dyscrasias like haemophilia, 7. Patients not willing for screening. RESULTS AND CONCLUSION: The present study shows no association between lichen planus and hepatitis C infection. Based on this result, it can be concluded that anti-HCV antibody testing is not necessarily required in lichen planus patients having no risk factors for HCV infection in this geographic region.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Lichen Planus ; Hepatitis C virus.
Subjects: MEDICAL > Dermatology Venereology and Leprosy
Depositing User: Punitha K
Date Deposited: 05 May 2018 08:29
Last Modified: 05 May 2018 08:29

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