A Study on the Usefulness of Fourth Generation Elisa (P24 Antigen and Antibody) for Early Detection of HIV Infection in the High Risk Group

Sukanya, G (2015) A Study on the Usefulness of Fourth Generation Elisa (P24 Antigen and Antibody) for Early Detection of HIV Infection in the High Risk Group. Masters thesis, Madras Medical College, Chennai.


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INTRODUCTION: AIDS was postulated initially as an infective condition way back in 1981 (Gotlieb et al). Worldwide there are forty million population living with Human Immunodeficiency Virus (HIV)/ Acquired Immuno Deficiency Syndrome (AIDS). Within a span of four decades, it has established to become a global pandemic imposing a major threat to different walks of life. It has immense effect on social as well as economic perspectives of Nations. Projections of future mortality and morbidity due to HIV are a useful aid in deciding on priorities for health research, capital investment and training. AIMS AND OBJECTIVES: To detect HIV infection using Fourth Generation Enzyme Linked Immunosorbent Assay and to compare the results of Test 1 (Fourth Generation ELISA) with Test 2 (Rapid Assay). METHODOLOGY: 200 patients consisting of High Risk Group and Contacts of High Risk Group attending the STI Out Patient Department, Institute of Venereology, Madras Medical College/RGGGH, Chennai were enrolled for the study. Fourth Generation ELISA for HIV infection was conducted on these selected patients along with routinely done Rapid Assay for HIV infection. RESULTS: The percentage of patients tested Positive by Fourth Generation ELISA out of the 200 study group was 37% and Negative was 63%. The detection rate of HIV Positivity by Rapid Assay in High Risk Group was 11% ad Negative was 89%. CONCLUSION: In this study, in most of the categories, the percentage of HIV Positivity detected by Fourth Generation ELISA was higher than that detected by Rapid Assay showing that Fourth Generation ELISA is a more sensitive test than Rapid Assay. A late diagnosis of HIV infection can result in increased transmission, morbidity, mortality and cost to health care services. Hence, early detection of HIV infection by Fourth Generation ELISA during the window period prevents transmission and above all improves the chances of early intervention.

Item Type: Thesis (Masters)
Uncontrolled Keywords: HIV ; Fourth Generation ELISA ; Rapid Assay.
Subjects: MEDICAL > Dermatology Venereology and Leprosy
Depositing User: Punitha K
Date Deposited: 05 May 2018 05:46
Last Modified: 05 May 2018 05:46
URI: http://repository-tnmgrmu.ac.in/id/eprint/7479

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