Clinico Histopathological Correlation in Various Spectrum of Leprosy

Amala, B (2015) Clinico Histopathological Correlation in Various Spectrum of Leprosy. Masters thesis, Madras Medical College, Chennai.


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INTRODUCTION: Leprosy is a chronic, infectious disease caused by Mycobacterium leprae. It is classified into five groups based on clinical, histological, microbiological and immunological criteria (Ridley & Jopling Classification). However, a great variation has been observed in the interpretation of histopathological examination of skin biopsies and clinical presentation of the disease. Histopathological examination of skin provides confirmatory diagnosis in suspected cases and gives indication of progression and regression of disease under treatment. This study is intended to demonstrate the concordance between clinical and histopathological diagnosis in leprosy. METHOD: All cases attending the Hansen OPD were examined clinically and Slit Skin Smear was taken and stained with Ziehl-Neelsen stain for Acid Fast Bacilli. Skin Biopsy specimen was obtained from clinically diagnosed cases of Leprosy and stained with Hematoxylin & Eosin and modified Fite Ferraco. The clinical diagnosis correlated with histopathology in all 50 cases. RESULT: The age of the patients was ranged from 7 to 65 years. The male to female ratio of patients was 4.5 to 1. The majority of cases were in the age group of 21-40 years belonging to low socioeconomic status. Borderline tuberculoid was the most common presentation. Highest parity was observed in LL (92.9%). Clincohistopathological agreement was seen in 40 (80%) cases, 10 (20%) cases shows disagreement. CONCLUSION: The clinical and histopathological features along with bacteriological index are useful than any single parameter in arriving definitive diagnosis and classification of the leprosy.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Leprosy ; Clinico Histopathological Correlation ; Various Spectrum.
Subjects: MEDICAL > Dermatology Venereology and Leprosy
Depositing User: Punitha K
Date Deposited: 05 May 2018 04:41
Last Modified: 05 May 2018 04:41

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