Study of Histology of Mammary Gland: Various Ages

Aruna, K (2015) Study of Histology of Mammary Gland: Various Ages. Masters thesis, Thanjavur Medical College, Thanjavur.


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BACKGROUND: Breast cancer is one of the common carcinoma in women. As epidemiological studies point out, the risk of developing cancer is more in case of older (>50 years) and nulliparous women as compared to parous women. AIM OF THE STUDY: To study the normal morphological changes with age and parity based on the lobular type; the changes in breast during menstrual cycle. Using immunohistochemical marker S100, the pattern and intensity of the myoepithelium in relation to age and lobular type; and its morphology during different phases of menstrual cycle were studied. MATERIAL & METHODS: A total of 36 normal breast tissues from surgical biopsies and mastectomy cases were taken up for study, using routine H & E staining. 11 samples with regular menstrual cycle and known LMP were taken to study changes during the menstrual cycle. 4 samples were used to study the myoepithelial changes using IHC with S100 marker. OBSERVATION: The most common Type in women of < 20 & > 50 years and nulliparous women was Lobular type I. Type II was almost equally distributed in all ages except in midforties. Type III was seen mainly in reproductive age group and parous women. The concordance of chronological date with that of morphological phase was 72.7%. IHC slides showed regular staining pattern in 20, 21, and 35 years of ages except in the slide of post-menopausal women (55 years), which showed irregular pattern. The intensity of the staining decreased with increasing age in the samples. CONCLUSION: The lobular type I was the predominant type in breast tissue women over 50 years and in the nulliparous women, increasing the risk for developing carcinoma, as compared to parous women and may need frequent follow up to detect early stages of carcinoma. IHC study showed decreased intensity and irregularity of staining in older post-menopausal women which may be due to the age related morphological changes the myoepithelium.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Histology ; Mammary Gland ; Various Ages.
Subjects: MEDICAL > Anatomy
Depositing User: Punitha K
Date Deposited: 05 May 2018 03:20
Last Modified: 26 Nov 2018 16:45

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