Study the Safety and Efficacy of Mesenchymal Stromal Cells (MSC) in the treatment of Recurrent High Fistula-in-ano: A Pilot study

Zeeshan, Rahman (2015) Study the Safety and Efficacy of Mesenchymal Stromal Cells (MSC) in the treatment of Recurrent High Fistula-in-ano: A Pilot study. Masters thesis, Christian Medical College, Vellore.

[img]
Preview
Text
220101115zeeshan_rahman.pdf

Download (3MB) | Preview

Abstract

OBJECTIVES: 1. To assess the feasibility and safety of Mesenchymal stromal cells (MSC) as a treatment option for recurrent high fistula-in-ano. 2. To study the efficacy of Mesenchymal Stromal Cells (MSC) in the treatment of recurrent high fistula-in-ano. METHOD: Patients with recurrent high fistula-in-ano of crypto glandular origin (n = 7) underwent injection of heterologous Mesenchymal stromal cells (MSC), 40 million units into the fistula tract and were followed up for a total of 2 months. If healing was not detected clinically at the end of 1 month, the patients underwent a repeat injection of Mesenchymal stromal cells (MSC) into the fistula tract. All patients were followed up at the end of 2 months clinically and MRI was done for patients who had clinical healing only. All patients were followed up for a duration of 4 months or till they were labeled as recurrence requiring another form of intervention. RESULTS: There were no adverse effects, reactions or worsening of primary disease in all 7 patients who underwent injections of Mesenchymal Stromal Cells (MSC) into the fistula tract. All patients were followed up for a period of 4 months and the procedure appeared to be safe, with no additional risk. At the end of 1 month fistula healing was observed in 4 out of 7 patients (57%) assessed clinically. Two patients had persistent fistula tracts and underwent a repeat sitting of MSC injection. At the end of 2 months 3 out of 7 (43%) patients had clinically healed fistula tracts and at the end of 4 months 1 out of 7 patients had clinically healed. Imaging done at 2 months following procedure revealed persistence of the fluid filled fistula tract in all the patients. CONCLUSION: The injection of heterologous Mesenchymal Stromal Cells (MSC) in the treatment of chronic non-healing crypto glandular fistula-in-ano appeared to be safe. However it did not heal the fistula tracts in this pilot study.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Mesenchymal Stromal Cells (MSC) ; Recurrent high fistula-in-ano ; Cryptoglandular.
Subjects: MEDICAL > General Surgery
Depositing User: Punitha K
Date Deposited: 04 May 2018 19:04
Last Modified: 04 May 2018 19:04
URI: http://repository-tnmgrmu.ac.in/id/eprint/7462

Actions (login required)

View Item View Item