Human Papilloma Virus (HPV) in squamous cell carcinoma of the oesophagus

Smit Kumar, - (2013) Human Papilloma Virus (HPV) in squamous cell carcinoma of the oesophagus. Masters thesis, Christian Medical College, Vellore.

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Abstract

AIMS AND OBJECTIVES: To evaluate the probable association of HPV infection with high risk genotypes 16 and 18 in patients with squamous cell oesophageal carcinoma. BACKGROUND: Oesophageal carcinomas are the eighth most common cancer worldwide and sixth most common cause of death worldwide from cancer. The etiology is unknown and many factors are involved in the carcinogenesis. The association of high risk HPV types16 and 18 in squamous cell carcinoma of the oesophagus is variable and still controversial in literature. There is limited data from India and no data available from South India. The objective of our study was to determine any association of HPV high risk types 16 and 18 in patient with squamous cell oesophageal cancer. METHODS: This was a prospective observational case control study done over 2 years. The total number of case participants (Group A) was 45 and control participants (Group B) were 38. The endoscopy biopsy tissue was collected from both the tumour and adjacent normal healthy mucosa in patients with squamous cell carcinoma of oesophagus. From the control participants biopsy was collected from the normal oesophageal mucosa. The collected samples were coded and sent for analysis for the presence of high risk HPV DNA types 16 and 18 by PCR. RESULTS: In this study high risk HPV DNA types 16 and 18 were not present in patients with squamous cell carcinoma of oesophagus. There was also absence of HPV in the control participants. However there is need for a larger study to investigate the probable association of HPV in the etiology of squamous cell carcinoma of oesophagus. CONCLUSIONS: 1. This study did not find any high risk HPV serotypes in patients with squamous cell carcinoma of the oesophagus. This is in concurrence with the evidence existing in the literature regarding HPV in low prevalence areas. 2. There exists geographical variation in the incidence of SCC oesophagus in India. However, in this study, HPV infection was not seen in patients from the different geographical areas within India. 3. The study also suggests the absence of high risk serotype HPV in the oesophageal mucosa of the control group as well. 4. There is a need of a larger multicentre study to substantiate the results of this study and to confirm or confidently rule out the association between HPV and oesophageal carcinoma in the Indian population.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Human Papilloma Virus (HPV) ; squamous cell carcinoma ; oesophagus.
Subjects: MEDICAL > General Surgery
Depositing User: Devi S
Date Deposited: 04 May 2018 04:16
Last Modified: 04 May 2018 06:18
URI: http://repository-tnmgrmu.ac.in/id/eprint/7437

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