Subassri, K (2009) A Study on Seethakazhichal. Masters thesis, Government Siddha Medical College, Palayamkottai.
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Abstract
AIM AND OBJECTIVES: Prevention and cure are the basic aims of all system of medicine. The basic emphasis of Siddha system is on positive health viz to prevent diseases by careful dieting and proper relaxation of the mind to achieve a totality of health. Seethakazhichal in children is a major health hazard in the developing countries like India, a common disease in the tropics and subtropics. If proper attention has not been given it may lead to many complications like dehydration, rectal prolapse, septicemia, etc. India, being densely populated with people of different socio economic status, children with poor sanitary facilities, lack of personal and environmental hygiene are the common victims of this disease. It forms one of the major causes of sickness among infants and children which causes a heavy economic burden to health services. At the present time, the dysentery causing bacteria are resistant to many antibiotics, polyresistant strains are widely spreading. As a Siddha paediatrician, an extra personal interest in the study of new drug for this common paediatric disease has been aimed. With this aim in mind, Madhulam pinju chooranam was tried in the patients suffering from seethakazhichal. OBJECTIVES: 1. To explore the most efficacious drug for Seetha Kazhichal. 2. To collect the literal evidences regarding the disease seethakazhical as per Siddha System. 3. To have a comparative study of the disease in Siddha and Modern aspect. (Amoebic dysentry and Bacillary dysentery). 4. To evaluate the disease Seethakazhical clinically by careful examination on aetiology, clinical features, differential diagnosis, investigations, diagnosis, treatment, diet, prognosis, complications etc. 5. To find out whether any adverse effects caused by Madhulam Pinju Choornam. 6. To evaluate the biochemical and pharmacological analysis of the drug. 7. To evaluate the efficacy of trail medicine on anti – microbial activity in vitro studies. 8. To have a clinical trail on the Seethakazhical affected children with Madhulam Pinju Chooranam. 9. To highlight the factors like hygienic condition, diet, climate on the incidence of this disease. 10. To make awareness for the prevention of the disease. MATERIALS AND METHODS: To find the efficacy of Madhulam Pinju Choornam, the following studies were carried out in the present investigation. I. Collection, Identification and confirmation of the raw drugs, for the preparation of Madhulam Pinju Choornam. II. Purification and processing of raw drugs. III. Preparation of trial drug. IV. Biochemical analysis of trial drug. V. Pharmacological studies of trial drug. VI. Antimicrobial studies of trial drug. VII. Clinical trials. The clinical study on seetha kazhichal was carried out in the outpatient and in-patient department (postgraduate) of kuzhanthai maruthuvam at government siddha medical college palayamkottai. Selection of cases: Twenty one cases of both sexes 11 male and 10 female in the age group between 2 years to twelve years were selected from the out patient department and admitted in the post-graduate kuzhanthai maruthuvam ward. The diagnosis was confirmed by clinical and laboratory criteria. Study of siddha clinical diagnosis The following siddha methods of diagnosis were employed: poriyalarithal, pulanaalarithal, mukkutra nilai, ezhu udal thathukkal, envagai thervugal, neerkuri, neikuri etc. Evaluation of clinical parameters: During admission the patients had passage of loose stools frequently. The loose stools were often mixed with blood and mucus and associated with lower abdominal pain and tenesmus. Patients having signs of severe dehydration and in need of emergency care were excluded from this study. Clinical investigations: Stools examination: Stools were examined macroscopically for Niram (colour), Nurai (froth), Erugal (solid), Elgal (semisolid or liquid) and microscopically for ova, cyst, trophozoites of entamoeba histolytica, occultblood, culture for shigella sp etc. Routine blood and urine examinations were done for all cases. Case proforma: All clinical signs and symptoms of seetha kazhichal, history of present and past illness, personal history, nutritional history, family history, immunizational history, laboratory investigations and management methods were systemically recorded in a proforma for analysis. Administration of trial medicine: The trial medicine used in the study is “Madhulam Pinju chooranam”. Preparation and properties, biochemical analysis, pharmacological studies and antimicrobial activity of the drug are dealt in detail in annexures. SUMMARY: Seethakazhichal (Dysentery) is a pandemic disease affecting mainly the large intestine and very common in children as per the Siddha and Modern Systems of Medicine. To treat children with Seethakazhichal, a Siddha Trial Drug; Madhulam pinju Choornam has been prepared. The collection, confirmation and purification of all ingredients have been described. The method of preparation of Madhulam pinju Choornam has also been described. The biochemical analysis of the Trial Drug shows the presence of aminoacids, unsaturated compounds, tannic acid, ferrous iron, starch and the results have been tabulated and discussed. The pharmacological effects such as antispasmodic, antidiarrhoeal, acute and chronic anti-inflammatory, antipyretic and styptic effects of Trial drug have been studied and the results have been tabulated and disussed. The antimicrobial actions of the Trial Drug on enteroinvasive microbes such as E.coli, Klebsiella, Shigella sp., Salmonella sps., and Staphylococcal sp., have also been studied and the results have been tabulated and discussed. The Trial Drug, Madhulam pinju Choornam has been used to treat 21 inpatients from (from Mar 08 to Dec 08) of children affected by Seethakazhichal. Dehydrated children, children having lactose intolerance and in need of emergency treatment were excluded for this study. Before treatment, the signs and symptoms for Seethakazhichal are noticed and confirmed by clinical analyses. During treatment, the dose of 250 mg to 1.0gm of Madhulam pinju Choornam, thrice a day after meals, along with buttermilk has been given to children affected by Seethakazhichal depending on their age, body weight and severeness of the disease. No side effect or adverse effect has been noticed during treatment with Madhulam pinju Choornam. By analysing and taking into consideration of all these results, it is inferred that the Madhulam pinju Choornam has effective actions in controlling the Seethakazhichal. CONCLUSION: Since Madhulam pinju Choornam has significant antimicrobial effects on intestinal microbes such as E.coli, Klebsiella, Shigella sp., Salmonella typhi, Salmonella paratyphi, and Staphylococcal sp., it has shown very good result in controlling bacillary dysentery. In the present observation, it is also proved that it is an effective treatment for amoebic dysentery. The Biochemical analysis and the pharmacological effects of this drug, shows that these substances not only help to eradicate microorganisms in the intestine, or bring the normalcy in the physiology of intestinal tissues, but also act as supplement for various vitamins, aminoacids and minerals which also contribute their share to regain the health of the patients. Apart from these, no adverse effects were observed in the Madhulam pinju Choornam treated patients. This drug is a herbal product, easily available, harmless to infants and children and hence it may be recommended for bacillary and amoebic dysentery. The dose of the drug used in the present study, is proved as adequate to use it as a paediatric drug to treat children with Seethakazhichal (dysentery) by child specialist.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Amoebic dysentry ; Bacillary dysentery ; Seethakazhical ; Madhulam Pinju Choornam. |
| Subjects: | AYUSH > Kuzhanthai Maruthuvam |
| Depositing User: | Kambaraman B |
| Date Deposited: | 24 Apr 2018 15:46 |
| Last Modified: | 29 Dec 2018 16:47 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/7287 |
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