Sudhakar, S (2014) Development of Simvastatin Loaded Nanostructured Lipid Carriers Based Hydrogels for Diabetic Wound Healing. Masters thesis, College of Pharmacy, Madurai Medical College, Madurai, Tamil Nadu, India.
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Abstract
Adult skin consists of two major tissue layers: a keratinized stratified epidermis and an underlying thick layer of collagen-rich dermal connective tissue providing support and nourishment. Appendages such as hairs and glands are derived from, and linked to, the epidermis but project deep into the dermal layer. Because the skin serves as a protective barrier against the outside world, any break in it must be efficiently mended. The hot homogenization was a useful method for the successfulincorporation of simvastatin inNanostructured lipid carrier with higher EE, sustained drug release and smaller particle size.The result indicates that NLC Based HG enhanced the permeation, sustained the drug release and enhanced the drug release at the site of action due to submicron size of lipid nanoparticles and gel matrix of chitosan HG. Thus the NLC based HG can be used as novel drug delivery carrier for skin targeting of simvastatin for its diabetic wound healing action.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Development; Simvastatin; Nanostructured Lipid; Carriers Based Hydrogels; Diabetic Wound Healing |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 30 Jun 2017 06:51 |
| Last Modified: | 30 Jun 2017 06:51 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/726 |
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