Anti – Streptolys in O Titers In Normal Healthy Children of 5-15 Years in Chennai City

Kesavan, S (2007) Anti – Streptolys in O Titers In Normal Healthy Children of 5-15 Years in Chennai City. Masters thesis, Madras Medical College, Chennai.


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INTRODUCTION: Group A Streptococcal infections and their late sequelae like rheumatic fever and rheumatic heart disease remain an important and major health problem in India. The incidence of rheumatic fever varies from 0.2 to 0.75 per 1000 children per year in school children of age 5 to 15 years. The prevalence of rheumatic heart disease varies from 1 to 5.4 per 1000 children 1. Such data have emphasized the importance of accurate clinical diagnosis often requiring laboratory confirmation of preceding Group A streptococcal infection. Group A streptococcus also known, as Streptococcus pyogenes is a common cause of infections of upper respiratory tact and the skin in the children. It is less common cause of perianal cellulitis, vaginitis, septicemia, pneumonia, endocarditis, pericarditis, osteomyelitis, suppurative arthritis, myositis, cellulitis, and omphalitis. These microorganisms are also the cause of two distinct clinical conditions scarlet fever and erysipelas, as well as toxic shock syndrome and necrotizing fascitis. Group A Streptococcus is also the cause of two potentially serious non-suppurative complications namely rheumatic fever and acute glomerulo nephritis. AIM OF THE STUDY: 1. To estimate the upper limit of normal value (ULN) of antistreptolysin O in healthy children of 5 to 15 years in Chennai city. 2. To compare the variation in titer with reference to age and socioeconomic status. DISCUSSION: One of the most important parameter to identify the recent streptococcal infection in a child who is suspected to have rheumatic fever is ASO titer. The evidence of recent streptococcal infection should be there to diagnose rheumatic fever which forms a part of Jones Criteria (1992)10 .The ASO titer seems to be influenced by various demographic factors like age, environmental factors, etc leading on to wide range of titer values, observed from different studies globally. It has also been reported that the upper limit of normal titer varies over a period, even within the same geographical area. All these facts necessitate to define the upper limit of normal for individual population, as well as to be confirmed periodically to observe any change in the value to higher or lower side. CONCLUSION: The antistreptolysin O level in healthy children of age group of 5 to 15 years in Chennai city is 227 IU/ml. This level can be taken as upper limit of normal, while considering the diagnosis of post group A Streptococcal infections in our population.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Anti ; Streptolys ; O Titers ; Normal Healthy Children ; 5-15 Years ; Chennai City
Subjects: MEDICAL > Paediatrics
Depositing User: Ravindran C
Date Deposited: 20 Apr 2018 07:13
Last Modified: 20 Apr 2018 07:13

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