Joan of Arc, V (2013) Pre-clinical and Clinical study on Pavattaiver Kudineer Chooranam for Hepatoprotective Activity in the management of Kalleeral Noi (Alcoholic Liver Disease) and Pre-clinical and Clinical study on Gandhaga Maathirai for H1 Histamine Antagonistic activity in the management of Kaanakadi (Urticaria). Masters thesis, National Institute of Siddha, Chennai.
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Abstract
The literary evidence strongly support the Hepatoprotective activity of Pavattai ver Kudineer choornam. The drug Pavattai ver has been selected for this study to evaluate its efficacy on the Hepatoprotective activity in the management of Kalleeral noi (Alcoholic Liver Disease). Biochemical analysis of the drug Pavattai ver kudineer choornam reveals the presence of, Iron, phosphate, alluminum, starch, sodium, alkaloids, reducing sugars and ammonia. The Preclinical evalution (acute oral toxicity study) of the drug was carried out as per OECD 425 guideline in Vels College of pharmacy, Chennai. The result shows safety of the drug for human administration In the toxicological studies, the drug does not exhibit any mortality upto the dose of 5000mg/kg/po. In the pharmacological studies the drug Pavattaiver kudineer chooranam exihibits significant hepatoprotective activity. From the clinical study 85% of patients relieved from Anorexia, 76.48% of patients relieved from Malaise, 68.75% of patients relieved from Nausea, 80% of patients relieved from vomiting, 75% of patients relieved upper Abdominal pain, 57.15% of patients relieved from Jaundice and no adverse effects were observed during trial period. From the statistical analysis-paired ‘t’ test, the drug pavattaiver kudineer Chooranam is satistically significant. Statistically, the paired ‘t’ test shows statistical significance for symptoms before and after the treatment.(p<0.0001) The drug Pavattaiver kudineer Chooranam has Hepatoprotective Activity, No side effects, No undoing effects, Encouraging clinical results. From the clinical and statistical analysis it is proved that the drug pavattai ver kudineer chooranam is statistically significant on Hepatoprotective activity, in the management of Kalleeral Noi (Alcoholic Liver Disease). CONCLUSION: From the literary evidences, phytochemical review and bio chemical, toxicological and pharmacological studies, it is concluded that drug Pavattai ver kudineer chooranam has significant Hepatoprotectiv Activity. Thus it gives a new hope in the management of Kalleeral Noi (Alcoholic Liver Disease).
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Pavattaiver Kudineer Chooranam ; Hepatoprotective Activity ; Kalleeral Noi ; Alcoholic Liver Disease ; Gandhaga Maathirai ; H1 Histamine Antagonistic activity ; Kaanakadi ; Urticaria ; Pre-clinical and Clinical study. |
| Subjects: | AYUSH > Gunapadam |
| Depositing User: | Kambaraman B |
| Date Deposited: | 20 Apr 2018 02:43 |
| Last Modified: | 21 Dec 2018 02:32 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/7146 |
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