Asvini, A (2008) A Study on Thaetran Karpam (Strychnos Potatorum) for Paandu Noi and A Study on Peenisa Choornam for Peenisam. Masters thesis, Government Siddha Medical College, Chennai.
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Abstract
The trial drug Thaetran karpam was selected for paandu noi based on evidence in siddha literature. • It is a herbal drug easily available, economical and preparation is simple. • The single drug was purified prepared as choornam and stored. • Pharmacognositcal study was carried in Central Research Institute for Siddha, Chennai – 106 and pharmacological studies were carried out in C.L. Baid Mehta College of Pharmacology Thorapakkam, Chennai. • Rf values were determined by T.L.C. • Phytochemical test showed the presence of alkaloids, sugar, steroids, proteins, tanins, phenols, flavonoids, saponins, aminoacid, glycosides and tannic acid. • Biochemical analysis showed the presence of calcium, iron. • Anti microbial study proved it to be an effective antibacterial agent. • Acute toxicity studies showed Thaetran did not exhibit any mortality in rats at 2000 mg/kg. • Animal experiments revealed that this drug is effective in improving the Hb and RBC levels in blood. It has good haematinic activity. • The administration of Thaetran karpam for 42 days did not produce any side effects. • Clinical trials showed Thaetran is effective in raising Hb levels upto 2 – 4 mg and effective in treating all the symptoms of paandu noi when treated for 48 days. • Out of 40 patients 32 showed better response in reductive of symptoms pallor, loss of appetite and fatigue. CONCLUSION: Thaetran karpam has significant haematinic property in animal studies. Anti microbial studies shows it is potent anti-bacterial agent. From the clinical study it is concluded that Thaetran karpam moderately rises Hb and RBC levels and is clinically effective in treating Paandu noi. It did not produce any adverse effects during chronic administration. Thaetran karpam needs further study with regard to the mechanism of action to develop it as a potent haematinic agent.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | Reg. No: 32051601 |
| Uncontrolled Keywords: | Thaetran Karpam (Strychnos Potatorum) ; Paandu Noi ; Peenisa Choornam ; Peenisam. |
| Subjects: | AYUSH > Gunapadam |
| Depositing User: | Kambaraman B |
| Date Deposited: | 20 Apr 2018 01:07 |
| Last Modified: | 29 Dec 2018 14:36 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/7132 |
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