Jayasudha, - (2007) Anti Spasmodic and Anti Histamine activities of Sadamanjil (Nardostachys Jatamansi) and Anti Spasmodic and Anti histamine activities of Amaiodu Parpam. Masters thesis, Government Siddha Medical College, Palayamkottai.
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Abstract
Anti Spasmodic and Anti Histamine activities of Sadamanjil (Nardostachys Jatamansi): AIM AND OBJECTIVES: The aim of this dissertation is to establish that the drug “Vetpalai Seeds Chooranam” is effective in ‘Azhal Keel Vayu’ (Osteo arthiritis) through pharmacological studies and clinical trials. In modern aspect, Azhal keel vayu has become a challenging problem to find out a permanent solution for this disease. In modern system of medicine analgesic and anti inflammatory drugs are used for such ailments, which produce side effects such as gastric irritation, nausea etc., Above problem urged the author to find a safe and easily available drug, which is not having any adverse effects. Since no analysis has been made so far in ‘Vetpalai seeds’ for the disease ‘Azhal Keel Vayu’. So, the author has selected the drug to prove its efficacy on the same. The Study is done in the following aspects. 1. Botanical Aspects, 2. Gunapadam Aspects, 3. Bio-chemical Analysis, 4. Pharmacological Analysis, 5. Clinical Assessment. SUMMARY: The drug vetpalai seeds chooranam (wrightia tinctoria was taken for the study to establish its anti - inflammatory, analgesic and anti – pyretic efficacy in Azhal keel vayu. The literatures were collected from various text books. The author has an idea about the identification, collection, botanical aspects, gunapadam aspects of vetpalai seeds and its effect in ‘Azhal Keel Vayu’ The chemical analysis of the drug was done in the bio – chemistry laboratory in Govt. Siddha Medical College, palayamkottai. The analytic report confirms that the drug contains calcium, chloride, sulphate, ferrous iron, aminoacid. The pharmacological analysis was done in pharmacology department of Govt. Siddha medical college, palayamkottai. The analysis established that the drug has got mild analgesic, significant acute anti inflammatory, significant chronic anti inflammatory and mild antipyretic effects. The clinical studies showed that the drug has got good response in Azhal keel vayu and investigation reports proved the results. During the clinical trial, it was inferred that the drug had no adverse effects. CONCLUSION: It is concluded that the trial drug vetpalai seeds has mild analgesic activity, significant acute anti inflammatory, significant chronic anti inflammatory and mild anti pyretic activity. Clinically it is effective in Azhal keel Vayu without carrying any adverse effects. Anti Spasmodic and Anti histamine activities of Amaiodu Parpam: AIM AND OBJECTIVES: The siddha system of medicine is becoming popular for its efficacy in chronic diseases. Nowadays eventhough, an advanced theoretical and practical achievements have been established, the mankind is in need of some proper solutions to various medical problems. The lifestyle and environment have been changed to greater extent which may lead to many unwanted and critical maladies. Among them, the most commonest problem in adults and geriatrics is keel vayu (arthritis) which is an inflammatory disease of joints. The arthritis especially in geriatrics which is degenerative in nature called Azhal keel vayu (osteo arthritis) has no proper curative methods in this modern world. The progressive prevalence of Azhal keel vayu is directly proportional to the age. In Radiological survey, people less than 45 years of age have only 2% of Azhal keel vayu, between the age of 45 to 64 years the prevelance is 30% and above the age of 65 years it is 68%. Finally the author has selected the Vedantha bairava mathirai [Koshaee anuboga vaidya Brahma Ragasium Page – 70] which is indicated specially for Azhal Keel Vayu . It is prepared from Lingam, Venkaram, Thippili and Karunabi. So the author for his dissertation work has selected ‘ Vedantha bairava mathirai’ and studied its efficacy in Azhal Keel Vayu. SUMMARY: The drug vedantha bairava mathirai has been taken to the study to establish its efficacy in Azhal keel vayu as an important aspect of this dissertation work. The review of siddha literature about the drug and its significance in medicine in ancient days were collected. Informations about the drug from various literatures were also referred. Bio chemical analysis revealed that the drug has got sulphate, ferrous iron, unsaturated compound, amino acid and mercury. Pharmacological analysis established that the drug has got moderate analgesic, moderate acute and chronic anti – inflammatory and moderate antipyretic properties From the clinical assessment it is inferred that the drug has marked response in Azhal keel vayu. During the clinical trial the author has also inferred that the drug has no contraindications. The drug has no adverse effects. CONCLUSION: This is concluded that the drug vedantha bairava mathirai has got moderate analgesic activity. Moderate acute and chronic anti-inflammatory activity and moderate anti pyretic activity effective in Azhal keel vayu without causing any adverse effects.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Anti Spasmodic and Anti Histamine activities ; Sadamanjil Nardostachys Jatamansi ; Anti Spasmodic and Anti histamine activities ; Amaiodu Parpam. |
| Subjects: | AYUSH > Gunapadam |
| Depositing User: | Kambaraman B |
| Date Deposited: | 19 Apr 2018 15:13 |
| Last Modified: | 19 Apr 2018 15:13 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/7101 |
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