Talasila, Sindhoor (2014) Organically Functionalized Multiporous Alumino-Siloxane Aerogel Microspheres For Controlled Release Of Antiplatletic Drug Aspirin. Masters thesis, K M College of Pharmacy, Madurai, Tamil Nadu, India.
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Abstract
In the past few years there has been an exceptional growth in research focused on drug delivery systems. This tremendous growth in this field is due to the exploration in the field of medicine and possibilities that these systems offer to biomedicine, such as several drugs which have been synthesized and thereafter these drugs being formulated into suitable dosage forms for administration using new therapies which in turn improved the efficacy and safety. This gives a chance of delivering new complex drugs that otherwise would not have been possible. The improvement of therapeutic responses with continuous drug release (controlled drug release) patterns rather than pulsatile (conventional dosage forms). The opportunities that recent advances in material sciences and biotechnology offer to develop new physical and medical methods of drug delivery have to be well obliged. There has been an upward trend in designing new dosage forms and also make it biocompatible[1]. However, the real advance has emerged as the development of targeted delivery in which the drug acts in the target area of the body. For this type of system, site specific and disease specific drugs need to be used since it is vital to direct the drugs where they are specifically needed[2]. Additionally, the sustained release in which the drug is released over a period of time in a controlled fashion has also been revealed as a milestone of this type of technology. The work focused on the synthesis of new drug carrier for those drugs which require controlled drug release. The synthesis of this novel carrier brings with it a great hope in future as a potential carrier. The alumino siloxane aerogel microspheres showed both promising drug loading and drug release for which the results were confirmed. The functionalized inorganic multiporous channels act as the suitable candidate for the pH sensitive drug delivery. The drug would be released in the intestinal pH of 7.4 only. The results obtained proved that aerogels acts as a best candidate for the controlled drug delivery; releasing the drug in the required fashion there by increasing the bioavailability of the drug. Only since the past half a decade the researchers have realized the importance of aerogels in the field on pharmaceutical industry before which its main application was as in insulator in packaging materials. Exploration has been done on silica and funtionalization but this work was carried out on organically modified alumina silicate which is a step ahead The technique would be highly cost effective since no binders and enteric coating polymers need to be used. The number of excipients used for the formulation is also very low. This in turn is a novel approach a face changer for most of the drugs. This work is being extended for studying the biocompatibility of the aerogel microbeads. And it is planned to conduct the experiments on the rat model as a pharmacological evaluation. Research has to extend to the next level to see this type of dosage form in the market.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Organically; Functionalized; Multiporous; Alumino Siloxane; Aerogel Microspheres; Controlled Release; Antiplatletic Drug; Aspirin |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 30 Jun 2017 06:11 |
| Last Modified: | 30 Jun 2017 06:11 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/709 |
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