Mahalakshmi, T G (2013) A Toxicity study on Mupoora Chenduram. Masters thesis, National Institute of Siddha, Chennai.
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Abstract
The experimental formulation Mupoora chenduram has been chosen for our dissertation work described based on Anuboga vaithya navaneedham(part IV). The formulation prepared with ingredients of Pooram(Mercurous chloride), Lingam(Cinnabar), Rasachenduram(Red sulphide of mercury). The chosen formulation has been prescribed for Suram(Fever), Meganoi(Venereal disease), Gunmam(Peptic ulcer) in the Siddha system of medicine since time memorial ago. The aim of the research work was to study the safety of the experimental formulation by acute and 28 days Repeated Oral toxicity studies in the animal models. The ingredients of the preparation were purchased from a standard raw drug markets. All the individual components have been purified as per the Siddha literature and the formulation was prepared in NIS Gunapadam lab. Mupoora chenduram was analysed qualitatively, quantitatively and evaluate safety by acute and 28 days Repeated Oral toxicity studies. Initially the test drug was subjected to physicochemical analysis. It has given the pH and purity of the drug. Then the samples were analysed for chemical constituents. It reveals that the presence of important minerals. The ICP-OES results showed the variation in the elemental content of before and after purified samples. And the test drug showed a drastic reduction in mercury and phosphorus level compared to its raw materials. HR-SEM analyses indicates the easy absorption of the drug . The FTIR analysis indicates the fine purification & preparation was done in the assignment. The toxicological evaluations were conducted as per OECD guidelines. In Acute toxicity study there was no abnormal signs and mortality at dose levels(5mg/animal,50mg/animal,300mg/animal).Mortality was observed at dose level of 2000mg/animal. Long term toxicity study revealed that there was no significant change in body weight, water and food intake, hematological and bio chemical parameters. The histopathological study revealed the spleen shows congested red pulp at low dose, mid dose, high dose levels, the kidney shows intracytoplasmic vaculation at mid dose level and focal area of haemorrhages at high dose level. CONCLUSION: In siddha system the method of purification and preparation prescribed in the literature shows tremendous change in the chemical composition. Toxicity studies, Qualitative and quantitative analysis indicates the the Mupoora chenduram was highly safe in Thereapeutic value which is mentioned in literature.The quantitative analysis shows the proof by the drastic reduction in ppm levels of Mercury and Phosphorous in Mupoora chenduram,results of other quantitative analysis were normal. Based on these results it can be concluded that, the dose level of Mupoora chenduram 130 mg (kundriyalavu) mentioned in the Siddha Literature (Anuboga vaithiya navaneedham,part-IV)is the safety dose for human consumption. In forth coming days this study will be redoubling by doing the chronic toxicity study, evaluate the pharmacological activity, anti microbial activity and clinical trial.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg No. 32103603 |
| Uncontrolled Keywords: | Mupoora Chenduram ; Toxicity study. |
| Subjects: | AYUSH > Nanju Noolum Maruthuva Neethi Noolum |
| Depositing User: | Subramani R |
| Date Deposited: | 13 Apr 2018 03:52 |
| Last Modified: | 29 Dec 2018 17:14 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/6985 |
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