Shivasubramaniam, S (2013) A Study on Madhumegam. Masters thesis, Government Siddha Medical College, Palayamkottai.
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Abstract
Since the commonest disease in the society, number of sufferers increasing day by day. So that the author had chosen the disease, “Madhumegam” for his dissertation work. 20 - Out patients and 20 In patients of either sex were selected for the study at PG-I Pothu Maruthuvam department and administered with the trial medicine. The trial drug “Neerizhivu Choornam” 2 gm two times a day with butter milk was administered during the whole study period. The trial medicine was subjected to Biochemical and pharmacological analysis.At the end of the trial study, the majority of the patients showed good results. AIM AND OBJECTIVES: AIM: Preclinical and clinical study on Madhumegam (Type 2- DIABETES MELLITUS) and the drug of choice is Neerizhivu Chooranam. OBJECTIVES: 1. To evaluate the efficacy of siddha formulation Neerizhivu Chooranam for decreasing the blood glucose level in the treatment of Madhumegam. 2. To Prepare the trial drug Neerizhivu Chooranam as per Siddha literature (The Pharmacopoeia of Siddha Research Medicines - Specific Medicine) and to analysis the qualitative and quantitative constituents present in the trial drug. 3. To establish the toxicological profile by performing acute oral toxicity studies and sub chronic toxicity studies on mice and rats following who guidelines. 4. To have a notion of the range of the diseases with sex, age, occupation, social status, diet, hereditary, and paruvakaalam., etc. 5. To study the Safety and efficacy of the test drug through an open clinical trial. SUMMARY: Madhumegam is the most commonly occurring disease which affects both sexes, the age group above 40 yrs. By its prevalence it seeks proper medical attention in the early stage, otherwise it leads to several complications like diabetic retinopathy, neuropathy, nephro-angiopathy and diabetic foot ulcer etc. These complications are prevented by controlling this disease by proper treatment and diet management. So the author had chosen this disease and had provided more efforts. The disease is well correlated with “Diabetes mellitus” (NIDDM) due to its classical signs and symptoms. “Neerizhivu choornam” was taken as a trial medicine for this dissertation work. The aetiology, pathology, classification, clinical features, diagnosis, treatment and prevention were collected from available literatures from both Siddha system and modern system of medicine. In this study 40 patients of both sexes at 30 – 70 different age groups with classical clinical symptoms were selected and 20 patients were taken as in patients and another 20 patients were taken as out patients. All the patients were examined by Siddha methodology such as poriyal arithal, pulanal arithal, vinavuthal, envagai thervugal and naadi paritchai. According to modern methodology, routine investigations like blood, urine and motion were analysed in all cases. The trial medicine Neerizhivu choormam was administered to all the selected patients, in the dose of 2 gm ; 2 times a day ; with Butter milk. Among O.P and I.P patients, all cases showed significant symptomatic improvement. Poly uria, nocturia, excessive appetite, numbness, tiredness and burning of foot were also reduced. Blood sugar and urine sugar was with in normal limit for 85% of cases, whereas 15% of cases showed moderate decrease in blood and urine sugar. All the durgs in Neerizhivu choornam are purely herbal. The potent antidiabetic drugs are Aavarai, kadukaai, Thetran vithai and vilam pisin as per siddha literature. Biochemical Analysis of Neerizhivu choornam showed the presence of calcium, sulphate, ferrous iron, unsaturated compounds, tannic acids and reducing sugar. Pharmacological study – The trial drug neerizhivu chooranam was oral anti – hyperglycemic effect was observed. CONCLUSION: • In this research clinical results found to be good in 85% of IP cases, 90% of Op cases, Fair in 15% of IP cases, 10% of Op cases. • Clinically the trial medicine was very effective to the suffering patients and relieved from the symptoms. • Further follow up of all these patients showed efficacy of medicine. • Clinical study showed no adverse effects of trial medicine during this study. • So it is concluded that madhumegam is controlled by Neerizhivu chooranam.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg. No. 32101010 |
| Uncontrolled Keywords: | Madhumegam ; Diabetes Mellitus ; Neezhivu Chooranam. |
| Subjects: | AYUSH > Maruthuvam |
| Depositing User: | Subramani R |
| Date Deposited: | 12 Apr 2018 18:13 |
| Last Modified: | 29 Dec 2018 15:46 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/6967 |
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