Influence of Natural and Synthetic Polymers on Formulation and Evaluation of Lamivudine Matrix Tablets.

Vikram, K (2014) Influence of Natural and Synthetic Polymers on Formulation and Evaluation of Lamivudine Matrix Tablets. Masters thesis, Padmavathi College of Pharmacy, Dharmapuri, Tamilnadu, India.


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Treatment of acute disease or a chronic illness has been mostly accomplished by delivery of drugs to patients using various pharmaceutical dosage forms including tablets, capsules, pills, suppositories, creams, ointments, liquids, aerosols, and injectables as drug carriers. Drug may be administered by variety of routes but oral administration is adopted wherever possible. It is safest, easiest, and most economical route of drug administration. Amongst drugs that are administered orally solid oral dosage forms i.e. tablets and capsules, represent the preferred class of products. Out of the two oral solid dosage forms, the tablets have number of advantages like tamper proof, low cost, and speed of manufacturing (direct compression), ease of administration, patient compliance, and flexibility in formulation etc. In this study matrix tablet of Lamivudine was prepared by wet granulation technique, using Rosin gum, Xanthan gum, Locust bean gum, Eudragit RL 100 and Eudragit RS 100 polymers alone as retardant. It was found that increase in the concentration in polymeric ratio decreases the drug release and able to sustain for 12 hours. The formulation F5 and F14 containing 40% of Rosin gum , 35% of Xanthan gum showed good drug release with good matrix integrity. Different parameters like hardness, friability, weight variation, drug content uniformity, in-vitro drug release etc. were evaluated for these formulations. Based on these results formulations F5 and F14 were found to be the most promising formulations. The optimized formulations F5 and F14 follows Higuchi’s plot since the regression coefficient is 0.9128 and 0.9253 and plots were also found to be linear, this confirms that the drug release through the matrix was diffusion. Stability studies were conducted for the optimized formulations as per ICH guidelines for a period of 90 days which revealed the stability of the formulations. The results suggest that the developed sustained-release tablets of lamivudine could perform better than conventional dosage forms, leading to improve efficacy and better patient compliance. Thus the aim of this study was achieved. Further preclinical and clinical studies are required to evaluate the efficacy of these formulations of Lamivudine in the management of HIV.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Influence; Naturall; Synthetic Polymers; Formulation; Evaluation; Lamivudine Matrix Tablets
Subjects: PHARMACY > Pharmaceutics
Depositing User: Ravindran C
Date Deposited: 30 Jun 2017 05:32
Last Modified: 30 Jun 2017 05:32

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