David Suvarna Raju, Parimi (2013) Clinical Profile of Children with Osteosarcoma and Outcome of Children Treated for Osteosarcoma on Two Protocols and Quality of Life Among those who Had Amputation Versus Limb Sparing Surgery. Masters thesis, Christian Medical College, Vellore.
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Abstract
OBJECTIVES: To study the clinical profile of children with osteosarcoma and outcome of children treated for osteosarcoma on two chemotherapy protocols. To look at treatment refusal and abandonment in the study population. To compare the quality of life in children with osteosarcoma who had amputation versus limb sparing surgery. METHODS: Variables: outcomes: Survival based on age at diagnosis, localised vs metastatic disease, high grade vs low or intermediate grade tumours, extremity vs axial skeleton tumours as well as chemotherapy used in these patients. predictors: Treatment complications, deformities, potential confounders: Socioeconomic factors- Poorer patients received CDDP+DOX Data Sources/measurement: Data sources are taken from Medical records of all these patients with Osteosarcoma. And also from the details from Chemotherapy records. Bias: No bias. Sample size: all children with osteosarcoma registered under pediatric Hemato-Oncology will be included in the study. Statistical methods: The data will be analysed using SPSS package 16.0 version. Tests of significance to be used are Chi-square tests, paired sample tests and Wilcoxon signed ranked tests. RESULTS: Study included 81 children. Male: Female ratio 1.07. Mean age at presentation was 11.4 years. Pain with swelling was most common symptom. Most common site was distal femur. 66% children completed treatment. Overall survival is 48% and event free survival is 41%. Abandonment rate was 22%. 50% in MAP group and 40% in CD group had good response to pre-op chemotherapy. 66% of children in CD group had amputation compared to 35% in MAP group. 57% in CD group and 76% in MAP group completed treatment. Abandonment rate was higher in CD group 38%, compared to 10% in MAP group. For quality of life 33/35 survivors responded. All those who had limb salvage surgery rated themselves to be having a good QOL.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Clinical Profile ; Children ; Osteosarcoma ; Outcome ; Treatment ; Amputation ; Limb Sparing Surgery. |
| Subjects: | MEDICAL > Paediatrics |
| Depositing User: | Ravindran C |
| Date Deposited: | 11 Apr 2018 08:28 |
| Last Modified: | 06 Jan 2019 11:54 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/6943 |
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