Evaluation of central neuropathy in type 2 diabetes Case - control study.

Prasanna Venkatesan, E (2014) Evaluation of central neuropathy in type 2 diabetes Case - control study. Masters thesis, PSG Institute of Medical Sciences and Research, Coimbatore.


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Introduction: Diabetes mellitus (DM) is a global pandemic affecting almost every organ in the body. Peripheral nervous system involvement in diabetes is well known but there are not much studies on central nervous system involvement. Visual evoked potential(VEP) is a sensitive, non invasive test to detect central demyelination of optic nerve. Aims: To compare the visual evoked potentials in type-2 DM patients with that of healthy controls and to find out if any correlation is there with the duration or glycemic control of the disease . Materials and methods: We included 50 DM patients and 50 age and sex matched controls. Patients with previous stroke, demyelination, diabetic retinopathy and other opthalmological disorders were excluded. VEP was recorded using pattern reversal stimulation with EMG RMS MARK II machine and p100 latency was measured. Results: P100 latencies (ms) was significantly prolonged in diabetics with mean ± SD of (111.24 ±5.28 ms) as compared to controls (101.30 ± 1.66 ms) with p value <0.003. Also there was significant correlation between duration of DM and P100 latency prolongation but no significant correlation was present between glycemic control of patients and P100 latency. Conclusion: Abnormal VEP may be due to structural damage to myelinated optic nerve fibres or retinal ganglion cells and it occurs even before development of retinopathy. Hence VEP can be a used as an early marker for central neuropathy and offers an opportunity for early management.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Central neuropathy; type 2 diabetes ; case - control study.
Subjects: MEDICAL > Neurology
Depositing User: Kambaraman B
Date Deposited: 30 Jun 2017 03:32
Last Modified: 30 Jun 2017 06:44
URI: http://repository-tnmgrmu.ac.in/id/eprint/693

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