Autonomic dysfunction in chronic inflammatory demyelinating polyneuropathy.

Sureshbabu, - (2014) Autonomic dysfunction in chronic inflammatory demyelinating polyneuropathy. Masters thesis, Christian Medical College, Vellore.


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Objective: To assess the frequency, severity and spectrum of autonomic dysfunction in patients with chronic inflammatory demyelinating polyneuropathy and to correlate autonomic dysfunction with the associated sensory motor deficits. Methods: Autonomic function was prospectively analyzed in 23 patients meeting CIDP criteria .Autonomic dysfunction was quantified by quantitative autonomic function tests (AFTs) using Finopres. The degree of autonomic dysfunction quantified by using modified CASS. Heart rate variability was assessed using power spectrum analysis. Autonomic symptoms quantified by using COMPASS 31. Severity of neurologic deficits was measured with total neuropathy score (TNS). Results: Patients mean age was 47.14±13.46 years with duration of illness 4.48±4.30 years. 15 of 23(65%) patients having autonomic symptoms, common symptoms were bowel and sicca symptoms. Autonomic deficits were common (Modified CASS = 3.26 ± 1.91) (19/23; 82%) with moderate severity 11/23(47.8%).Autonomic dysfunction involving both parasympathetic (70%) and sympathetic arms (60%).Spectral analysis of HRV showing abnormality in sympathetic arm. Autonomic deficits did not relate to autonomic symptoms severity, somatic deficits, duration of disease, severity of disease and temporal profile of disease Conclusion: .There is a high Prevalence of autonomic dysfunction in patients with CIDP(80%). The parasympathetic arm (70%)was more involved than sympathetic(60%).

Item Type: Thesis (Masters)
Uncontrolled Keywords: Autonomic dysfunction ; chronic inflammatory ; demyelinating ; polyneuropathy.
Subjects: MEDICAL > Neurology
Depositing User: Kambaraman B
Date Deposited: 30 Jun 2017 03:24
Last Modified: 30 Jun 2017 06:39

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