Clinical and Electroencephalographic profile of Seizures in patients with Alcohol Dependence.

Vijayashankar, P (2014) Clinical and Electroencephalographic profile of Seizures in patients with Alcohol Dependence. Masters thesis, Stanley Medical College, Chennai.


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Alcohol is used in almost all the countries as a social drink. The prevalence of alcohol abuse is more common in developed countries. Now a days there is a increasing trend was seen in developing countries also. In the United States and Australia 80% of men and 60% of women consumes alcohol at some point of time in their lifetime. Alcohol abuse was one of the five most important risk factors causing global burden of disease and disability was associated with epilepsy. Epilepsy is one of the most common neurologic presentations. Worldwide, there are 50 million people living with epilepsy and most of them (80%) were living in developing countries. An annual incidence of 40 -70 per 1,00,000 people were in industrialized countries. Epilepsy contributed 0.5% of the global disease burden and more than 7 million disability adjusted life years. The incidence of unprovoked seizures was 370 per 1, 00,000 in Iceland and 800 per 1,00,000 in Poland .7 The most common age for first independent drinking without a family member is about 15 years. It varies among countries and depends up on the culture, but it has not changed much in decades. Heavy drinking was commonly observed in the adolescent age group of 18 years to 22 years. Alcohol withdrawal seizures occur most frequently within 6 -48 hours of abstinence from alcohol. The recurrent alcohol withdrawal seizures reduces the threshold for seizures by kindling effect. Seizures were very common in the alcohol withdrawal state. Hence seizures in an alcoholic were usually considered as alcohol withdrawal seizures. Recent literatures suggest that the seizures in alcoholics were not only due to alcohol withdrawal, it may be due to alcohol dependence. It can be easily differentiated by a detailed drinking history, clinical examination and to do the necessary supportive investigations such as EEG, MRI Brain to evaluate the cause of the seizures and treat the patient appropriately. CONCLUSION : - Alcohol dependent patients have an increased propensity to develop seizures. - Alcohol dependence seizures affected the most productive age group of males in our society as demonstrated in our study. - Alcohol dependence seizures is not a homogenous entity, it is a heterogeneous entity consisting of patients with alcohol related seizures, alcohol withdrawal seizures and epilepsy patients who developed alcohol dependence later in their life. - The duration of alcohol consumption is directly correlated with a higher frequency of seizures. - The more the consumption of alcohol per day the higher the frequency of alcohol withdrawal seizures. - Alcohol withdrawal seizure patients had a higher frequency of generalized seizures. - Epilepsy patients who developed alcohol dependence later in their life had a higher frequency of complex partial seizures.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Clinical and Electroencephalographic profile ; Seizures ; patients ; Alcohol Dependence.
Subjects: MEDICAL > Neurology
Depositing User: Kambaraman B
Date Deposited: 30 Jun 2017 03:15
Last Modified: 30 Jun 2017 06:27

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