Prospective Randomised study on Postoperative Analgesia for Caesarean Section with Intrathecal Buprenorphine

Sasikumar, P (2013) Prospective Randomised study on Postoperative Analgesia for Caesarean Section with Intrathecal Buprenorphine. Masters thesis, Madras Medical College, Chennai.


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SUMMARY: A clinical study was done to evaluate the efficacy, duration of post operative pain relief and to know the quality of analgesia provided by intrathecal opioids added to local anaesthetic agents. The study was undertaken in 60 patients of ASA I and II posted for elective cesarean section for post operative pain relief. Group A – 30 patients – received 1.7ml of hyperbaric 0.5% bupivacaine with buprenorphine 0.2ml (60μg). Group B – 30 patients – received 1.7ml of hyperbaric 0.5%bupivacaine with 0.2ml 0f 0.9% normal saline. - Onset of sensory analgesia is significantly increased (1-31/2min) in patients receiving buprenorphine than control group. - Onset of motor blockade also significantly increased in study group 1-5min. - Postoperative analgesia was upto 13-14hours in group A (study) with SD.96.33min than control group B 21/2 – 41/2 hours. - There was no statistically significant changes in pulse rate, respiratory rate, blood pressure , oxygen saturation and neonatal apgar score. - There was no respiratory depression in study group and few patients had a sedation score >3 which is statistically significant. There was no statistically significant complications in both groups. CONCLUSION: Intrathecal buprenorphine is suitable drug for postoperative analgesia in patients undergoing cesarean section, it enhances onset of sensory blockade without affecting motor blockade and sympathetic activity. Anaesthesia was superior when buprenorphine is mixed with bupivacaine (0.5%) as compared to bupivacaine alone. The benefits of opiates are significant when used intrathecally and outweighs the side effects. Subarachnoid block is easy to perform, more predictable and the drug is easily available. So this combination of drugs can be used for postoperative analgesia in elective cesarean section.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Postoperative Analgesia ; Caesarean Section ; Intrathecal Buprenorphine ; Prospective Randomised study.
Subjects: MEDICAL > Anaesthesiology
Depositing User: Kambaraman B
Date Deposited: 04 Apr 2018 18:06
Last Modified: 16 Apr 2018 17:43

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