Kayalvizhi, P (2013) A Prospective, Randomized Comparative study to evaluate the Efficacy and Safety of Epidural Bupivacaine Morphine with Ketamine Versus Epidural Bupivacaine with Morphine alone for Postoperative Analgesia After Major Abdominal Surgeries. Masters thesis, Madras Medical College, Chennai.
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Abstract
SUMMARY: We conducted a rondomised double blinded study in a group of 60 patients belonging to ASAI& II undergoing elective abdominal sugeries to evaluate the effect of adding low dose epidural ketamine to epidural bupivacaine and morphine. Two groups of 30 each were randomly taken and analysed. The summary of our study are • The two groups were comparable in terms of demographic profile such as age, sex, weight and height. • The mean time of onset of analgesia was 6.10(min) in group-I versus 12.53 in group-II. It was statistically significant with a P value of 0.001. • The mean duration of analgesia was 13.73 (hrs) in group-I versus 8.27 (hrs) in group-II. It was statistically significant with a P value of 0.001. • The median VAS score was 1 in group-I upto the mean duration of 13.73hrs and was 1 in group –II upto the mean duration of 8.27hrs. ,and is comparable between two groups. • The haemodynamic variables like heart rate, systolic, diastolic and mean blood pressures were comparable between the two groups. The incidence of morphine induced side effects and rescue analgesic requirement were less in group-I than group-II. Also none of the patients experienced ketamine related side effects CONCLUSION: We conclude that the addition of low dose (0.2mg/kg) epidural ketamine with bupivacaine and morphine accelerates the onset and duration of analgesia resulting in effective post operative analgesia in patients undergoing major abdominal surgeries without an increase in the incidence of side effects.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Epidural Bupivacaine Morphine ; Ketamine ; Epidural Bupivacaine ; Morphine alone ; Postoperative Analgesia ; After Major Abdominal Surgeries ; Prospective, Randomized Comparative study. |
| Subjects: | MEDICAL > Anaesthesiology |
| Depositing User: | Kambaraman B |
| Date Deposited: | 04 Apr 2018 17:30 |
| Last Modified: | 04 Apr 2018 17:30 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/6840 |
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