The Role of Ca19-9 in Predicting Tumor Resectability in Carcinoma of the Head of Pancreas

Aparna, M J (2013) The Role of Ca19-9 in Predicting Tumor Resectability in Carcinoma of the Head of Pancreas. Masters thesis, Stanley Medical College, Chennai.

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Abstract

BACKGROUND: To study the role of CA 19-9 in predicting the resectability of the tumor in the head of pancreas .During the management of pancreatic carcinoma, CA 19-9 are measured to monitor response to chemotherapy and early detection of local recurrence. Nonetheless ,its exact role in the preoperative evaluation to assess the operability of the tumor is controversial. MATERIALS AND METHODS: 30 patients diagnosed with carcinoma of the head of pancreas on the basis of CECT/MRCP during the study period of 2 years are included in the study. During the preoperative evaluation of these patients, CA 19-9 levels were measured and recorded. Patients who are medically unfit for surgery or those who did not warrant operative palliation are excluded from the study. After adequate preoperative preparation patients are taken up for surgery with either curative or palliative intent. During surgery the operative findings on the basis of which operability of the tumor is assessed, is documented and tabulated against corresponding values of CA 19-9. Then the diagnosis is confirmed based on the histopathological report. The operative findings and its relation to the CA 19-9 levels are analysed and the results are interpreted. RESULTS: Of the 30 patients who were operated, 13 patients had operable tumors and underwent WHIPPLES procedure and 17 of them had inoperable tumors and had to undergo palliative bypass procedures of some form. Of the 30 patients CA 19-9 levels were elevated in 9 patients and was normal in 21 patients. Among the 13 patients who had operable tumors, CA 19-9 was raised in 4 patients and was normal in 9 patients . Of the 17 patients who had inoperable tumors CA 19-9 was elevated in 5 patients and was normal in 12 patients. Among the 17 patients who had inoperable tumors,8 were diagnosed preoperatively, and of them CA 19-9 levels were raised in 2 patients and normal in 6 patients. In the group of 9 patients who had inoperable tumors diagnosed intraoperatively, CA 19-9 was raised in 4 of them and was normal in the remaining 5 of them. CONCLUSIONS: This study brings us to the conclusion that CA 19-9, as atumor marker has no role in predicting the tumor resectability in carcinoma of head of pancreas.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Role of Ca19-9 ; Predicting Tumor Resectability ; Carcinoma of the Head of Pancreas.
Subjects: MEDICAL > General Surgery
Depositing User: Devi S
Date Deposited: 03 Apr 2018 03:14
Last Modified: 03 Apr 2018 03:22
URI: http://repository-tnmgrmu.ac.in/id/eprint/6796

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