A Prospective COHORT study of One Hundred Cases of First Unprovoked Seizure.

Chandramouleeswaran, V (2007) A Prospective COHORT study of One Hundred Cases of First Unprovoked Seizure. Masters thesis, Stanley Medical College, Chennai.


Download (230kB) | Preview


Seizures have been recognized since ancient days. One of the earliest descriptions of generalized tonic-clonic seizure was recorded over 3000 years ago in Mesopotamia and it was attributed to the God of the Moon. Epileptic seizures were also described in ancient cultures of India, China and Egypt. The word seizure is derived from Latin word "sacire", meaning, "to take possession of" indicating that the person having a seizure is possessed or at least out of control. A seizure is a paroxysmal self limited event caused by an excessive electrical discharge of central nervous system. Epilepsy is a disorder characterized by recurrent seizures. A First Unprovoked Seizure (FUS) is a first seizure episode occurring in an individual without an identified proximate precipitant and it excludes seizures occurring after an acute insult to the central nervous system or with generalised systemic metabolic disturbance of the body. Unprovoked seizures can be further classified into: Remote symptomatic seizure (associated with stroke, head injury, tumour, infection etc) and idiopathic seizures (without history of neurological insult or a neurological deficit presumed to be present from birth). A first seizure is a frightening event for families and friends. But the patients may have a certain degree of confusion and reluctance to seek attention. The consequences of a diagnosis of “epilepsy” are serious both for the patients and their families. In the management of epilepsy, it is important to humanely guide and counsel the anxious patients. The consequences of a diagnosis and treatment must outweigh the risks of seizures recurrence. CONCLUSIONS : 1. Following an attack of first unprovoked seizure, lower educated male laborers preferred AED therapy for the fear of injury, loss of job or their life itself. 2. Recurrence rate in the treated and untreated group after a one year follow up stood at 14% and 20% respectively. 3. Most of the recurrence in the preferred group occurred between the third to sixth months and in the deferred within 3 months, inferring that the AED therapy did not have any role in preventing seizure recurrence beyond three months. 4. Effective counseling resulted in better compliance rate (85%).

Item Type: Thesis (Masters)
Uncontrolled Keywords: First Unprovoked Seizure ; One Hundred Cases ; A Prospective COHORT study.
Subjects: MEDICAL > Neurology
Depositing User: Kambaraman B
Date Deposited: 30 Jun 2017 02:52
Last Modified: 30 Jun 2017 05:53
URI: http://repository-tnmgrmu.ac.in/id/eprint/676

Actions (login required)

View Item View Item