Feasibility of Hybrid Conformal technique in treatment of Carcinoma Esophagus.

Rishan, T S (2015) Feasibility of Hybrid Conformal technique in treatment of Carcinoma Esophagus. Masters thesis, Cancer institute (WIA), Chennai.


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Aim of the study: To assess the feasibility of Hybrid conformal technique in treatment of Esophageal cancers thereby achieving a non inferior dose distribution, to reduce the volume of lung treated, and also to calculate the time taken for both. Materials and Methods: Twenty patients with carcinoma Esophagus were taken and their treatment plans were analyzed. All the patients underwent baseline pulmonary function tests, and compared with the same after treatment. The CTV,PTV, spinal cord, heart, and the lungs were contoured and planned. Patients were treated with hybrid technique that combines CT based 2-opposing AP/PA technique and conformal beams. They were compared with the all-IMRT plans. Dose volume histograms were calculated for the planning target volume, heart, and lungs. Lung volumes were drawn with volume of the lung receiving 30 Gy (V20) and the mean lung dose (MLD) were calculated. The time taken for the all-IMRT and Hybrid-conformal techniques were calculated. Results: Analyzation of both the techniques showed that, taking into account, the constraints for organs at risk, and given the full dose to the planning target volume, the dose distributions achieved was not inferior to that achieved in all IMRT plans. Dose volume histograms revealed that V20 and mean lung dose was lower in Hybrid conformal technique than all-IMRT plans, which was found to be statistically significant with a p-value of <0.05. The study also achieved cord and heart doses, as like the control plan. The time taken for Hybrid conformal technique was atleast 50% less compared to IMRT. Conclusion: Hybrid conformal technique will be a good alternative with which dose distributions achieved was not inferior to IMRT, along with reduction of both V20 and mean lung dose. The time taken for completion of treatment was also less compared to all IMRT plans, thereby leading to reduced treatment time. Reduction of lung doses might help in avoiding postoperative pulmonary complications like radiation pneumonitis, thereby improving the quality of life.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Esophageal Cancer; Hybrid Conformal Technique; IMRT; Two Opposing and Conformal Therapy; Radiation Pneumonitis; Treatment Related Pneumonitis.
Subjects: MEDICAL > Radio Therapy
Depositing User: Punitha K
Date Deposited: 28 Mar 2018 07:17
Last Modified: 28 Mar 2018 07:17
URI: http://repository-tnmgrmu.ac.in/id/eprint/6707

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