Poonkodi, N (2015) Assessment of thyroid dysfunction in patient receiving whole neck irradiation in head and neck malignancies. Masters thesis, Cancer institute (WIA), Chennai.
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Abstract
AIM: To Assess the incidence of thyroid dysfunction in patients receiving whole neck irradiation in head and neck malignancies.it is justified that routinely performed Thyroid function test (TFT) during routine follow up. Materials and methods: Fifty patients with locally advanced head and neck malignancies receiving whole neck irradiation for the period of one year were included in this study. Thyroid function tests (TFT) was done at baseline (Before start of treatment), after six months, and at the end of one year interval. RESULTS: Out of fifty patients included in this study, 39(78%) were males and 11 (22%) were females. All patients received radiation to neck >40Gy. Among 50 Patients received whole neck irradiation,20 patients had hypothyroidism with significant P value of 0.0001. 35 received chemotherapy concurrently and out of 35 patients 18 had hypothyroidism with 51.42% and 15 patients received only radiotherapy out of 15 patients 2 had hypothyroidism with 13.33%. Among them, 20patients had abnormal values; 15 Patients (30%) were found to have subclinical hypothyroidism and 5patients (10%) developed clinical Hypothyroidism. Out of 15 patients who had subclinical hypothyroidism seven patients in one year follow up and three patients in 6months follow up .In clinical hypothyroidism out of 5patients 4 were in one year follow up, one patient in 6months follow up.In concurrent chemo radiotherapy out of 35 patients 18 had hypothyroidism (51.42%)and in only radiotherapy 2 out of 15patients had hypothyroidism (13.33%),with P value of 0.0137 Conclusion: Thyroid dysfunction usually Hypothyroidism either Clinical or subclinical is a less recognized morbidity of external beam radiotherapy to head& neck exceeding the 40Gy radiation. Detecting hypothyroidism early and treating is preventing associated complications. Hence mandatory to made Thyroid function tests as a routine during follow up.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Head& Neck Cancer; Concurrent Chemo Radiotherapy; Hypothyroidism; Radiotherapy. |
| Subjects: | MEDICAL > Radio Therapy |
| Depositing User: | Punitha K |
| Date Deposited: | 28 Mar 2018 07:12 |
| Last Modified: | 28 Mar 2018 07:17 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/6706 |
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