Vithyatharan, K S (2009) Metabolic Syndrome in Hypothyroid Patients. Masters thesis, Madras Medical College, Chennai.
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Abstract
SUMMARY: Patients with hypothyroidism are at increased risk of obesity, elevated triglyceride, decreased HDL and hypertension and may have increased risk of Metabolic syndrome. A non randomized cross sectional Study was conducted in female primary hypothyroid patients who attended the Endocrinology OPD, Institute of Internal Medicine, Madras Medical College and Government General Hospital, Chennai. The aim of the study was to find the prevalence of Metabolic Syndrome in frankly hypothyroid patients with poor drug compliance for more than 3 months, subclinical hypothyroidism not started on levothyroxine, recently diagnosed hypothyroid patient not started levothyroxine. After applying inclusion and exclusion criteria, 55 female hypothyroid patients proved by thyroid hormone assay were selected for study after written consent. Detailed history including drug intake, clinical examination including anthropometric measurements were noted. After eight hours of fasting, blood drawn for fasting blood sugar and lipid profile. 22 patients (40%) and 27 patients (49.09%) of the study group were diagnosed to be metabolic syndrome as per IDF criteria and AHA/NHLBI 2005 criteriarespectively. Metabolic syndrome was increased in the study group than the general population. Majority were obese (BMI ≥ 25 kg/m2 - 61.82%) than centrally obese (WC ≥ 80 cms-43.64%). Elevated triglycerides, decreased HDL, hypertension and glucose intolerance were present in 60%, 89.09%, 32.73% and 47.27% of the study group respectively. Though studies do not associate glucose intolerance with hypothyroidism, the factors causing increased FBS in this study group remain obscure. Incidence of Metabolic syndrome increases with age and this was also true in our study. Subclinical hypothyroidism patients be treated in South East Asia where prevalence of diabetes, premature coronary artery disease and dyslipidemia are higher than the rest of the world. Affordable, accessible health care, health education including diet, exercise and drug compliance may halt the progression of diabetes, hypertension, obesity, premature coronary artery disease in this region The study group consists of small number of subjects. The study concludes that larger prospective study has to be performed to confirm the association of hypothyroidism and Metabolic syndrome. CONCLUSIONS: 1. Metabolic syndrome was increased in female frankly hypothyroid patients with poor drug compliance, subclinical hypothyroidism not started on levothyroxine, and newly diagnosed hypothyroid patient. 2. Prevalence of Metabolic syndrome is 40% and 49. 09% as per IDF and AHA/NHLBI 2005 criteria respectively in the study group which was higher than the general Population. 3. All the parameters of Metabolic syndrome like central obesity hypertension, decreased HDL, elevated triglycerides and glucose intolerance are increased in the study group. Majority of patients have generalized obesity rather than central obesity. 4. All clinical and subclinical hypothyroid patients should be screened for metabolic syndrome parameters and if identified should be treated aggressively. 5. Subclinical hypothyroidism should be treated in South East Asia where prevalence of diabetes, premature coronary artery disease and dyslipidemia are higher than the rest of the world though partly attributed due to genetic predisposition.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Metabolic Syndrome ; Hypothyroid Patients. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 28 Mar 2018 05:36 |
| Last Modified: | 31 Mar 2018 03:17 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/6699 |
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