Ramya, A (2015) Concurrent chemoradiotherapy in locally advanced squamous cell carcinoma of head and neck with capecitabine and weekly cisplatin. Masters thesis, Madras Medical College, Chennai.
|
Text
2009001ramyaa.pdf Download (4MB) | Preview |
Abstract
AIMS & OBJECTIVES: To assess the immediate loco regional response rates and acute toxicity in patients with locally advanced squamous cell carcinomas of the head and neck in Conventional radiotherapy with weekly Cisplatin and Capecitabine. MATERIALS AND METHODOLOGY: Single arm prospective study with 30 consecutive patients with locally advanced head and neck cancer presented to the department of radiotherapy, Madras medical college, Chennai. All patients were treated with conventional radiotherapy 66Gy along with weekly Inj.Cisplatin 40mg/m2 and T.capecitabine 500mg/m2 twice daily along with radiation. The immediate loco regional response rates were assessed clinically and radiologically 6 weeks after concurrent chemo radiotherapy. The toxicity profile of the treatment was assessed with RTOG acute morbidity scoring criteria and CTCAE Version 4. RESULTS: Among 30 patients, Ca Oropharynx was 9 patients, followed by Ca Hypopharynx 8 patients, Ca Oral cavity with 7 patients and Ca Supraglottis 6 patients. 73% of patients had complete response and 27% had partial response. Toxicities observed in the study were Mucositis grade 3 in 5 patients and grade 4 in 2 patients; Skin reactions grade 2 in 2 patients. Leucopenia grade 2 in 2 patients. Systemic toxicity diarrhea grade 1 was only in 2 patients. There was no renal toxicity, hand foot syndrome in this study. There was no treatment related deaths in this study. CONCLUSION: Concurrent chemoradiotherapy with Inj.Cisplatin and T.Capecitabine in locally advanced squamous cell carcinoma of head and neck cancer is better regimen with manageable toxicity with higher complete response rate.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Concurrent Chemoradiotherapy; Cisplatin; Capecitabine; Mucositis; Hand Foot Syndrome |
| Subjects: | MEDICAL > Radio Therapy |
| Depositing User: | Punitha K |
| Date Deposited: | 28 Mar 2018 05:41 |
| Last Modified: | 28 Mar 2018 05:41 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/6693 |
Actions (login required)
 |
View Item |
