Senthil Kumar, S (2009) Study on Nerve Conduction Abnormalities in Organo Phosphorus Poisoning. Masters thesis, Madras Medical College, Chennai.
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Abstract
CONCLUSIONS: Organophosphorous poisoning is most prevalent in the 21-30 age group. Incidence is more common in males. • Organophosphorous poisoning is more common among agricultural labourers and unskilled workers. • The most important cause for consumption of organophosphorous poison is self harm. • The common route of exposure is ingestion of poison and it is associated with clinical severity. • The quantity consumed has direct proportional relationship with severity of poisoning. • The duration of stay in the hospital has significant correlation with clinical severity. • The higher the clinical grade of poisoning at initial presentation more the need of ventilatory support and adverse the outcome. • The following parameters predict the need of ventilatory support, grade 3 clinical severity, proximal muscle affection, low values of day 1 serum cholinesterase. • Ingestion of OPCs produced abnormalities in Nerve Conduction Studies in the form of axonopathy, sensory neuropathy and demyelination. • Ingestion of Monocrotophos produced death in three patients and neuropathy in remaining patients. • Ingestion of Dimethoate produced all the three abnormalities in NCS. • Ingestion of Monocrotophos caused axonopathy and sensory neuropathy. SUMMARY: Organophosphorous poisoning is a menace to the human race both as a weapon of mass destruction and a misused pesticide of self harm. The case fatality rate exceeds 60% in developing countries where there are many pit falls in treatment protocol and research activities. So a comprehensive analysis of 29 patients of organophosphorous poisoning was done in Poison Centre, Government General hospital Chennai. All the cases included in the studied underwent detailed clinical evaluation, extensive laboratory work up and nerve conduction studies. Each patient was monitored periodically till the outcome. There were 24 males and 5 female patients. The predominant age group was 21- 30years. 28 patients were suicide attempts and 1 had accidental exposure. 27 of the patients were poisoned through the gastrointestinal route. One patient had inhalational poisoning and one patient had topical exposure. There were 9 different types of OP insecticide agents involved. According to Dreisbach clinical criteria at admission, all patients belong to the severe grade of poisoning. Serum cholinesterase levels had significant correlation with clinical severity, mechanical ventilation and outcome. Nerve conduction studies were done on the third or fourth week of hospital stay. Both upper and lower limb nerves were studied. Thirteen patients had evidence of OPIDP. Three patients had evidence of significant axonopathy, 6 patients had evidence of demyelination and 8 patients had evidence of sensory neuropathy.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Nerve Conduction Abnormalities ; Organo Phosphorus Poisoning. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 28 Mar 2018 05:29 |
| Last Modified: | 31 Mar 2018 02:36 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/6691 |
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