Mohit, Mathur (2009) Study on Co-relation between Serum Antioxidant Levels and Clinical Manifestation in Patients with Organophosphorus Poisoning. Masters thesis, Madras Medical College, Chennai.
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Abstract
CONCLUSIONS: The total Anti-oxidants were significantly elevated in patients with OPC Poisoning when compared to normal controls. • Individual Anti-oxidants like Super oxide dismutase (SOD), Catalase, Malonyl dialdehyde (MDA), Glutathione Reductase, Glutathione transferase were significantly elevated in patients with OPC Poisonig when compared to normal controls. • The elevated antioxidant levels could not be attributed to the individual type of OPC compound. • The elevated antioxidant levels could not be attributed to differences in sex, age, geographical location, treatment etc. • There was no significant difference in the levels of Total Antioxidants between the patients who survived and the patients who died. • There was no significant difference in the levels of Individual Antioxidants like Super oxide dismutase (SOD), Catalase, Malonyl diadehyde (MDA), Glutathione Reductase, Glutathione transferase between the patients who survived and the patients who died. • There was no significant difference between the levels of Total Anti-oxidants on Day 1 and Day 5 in patients with OPC poisoning. • There was no significant difference between the levels of Individual Anti-oxidants like Super oxide dismutase (SOD), Catalase, Malonyl Aldehyde (MDA), Glutathione Reductase, Glutathione transferase on Day 1 and Day 5 in patients with OPC poisoning. • There was significant reduction the Plasma Cholinesterase levels of patients with OPC Poisoning when compared with normal individuals. • There was significant reduction the RBC Cholinesterase levels of patients with OPC Poisoning when compared with normal individuals. • There was minimal increase in the levels of Plasma Cholinesterase and RBC cholinesterase by Day 5. • There was significant co-relation between the Peradeniya Organophosphorus Poisoning scale and the outcome, higher score indicating poor prognosis. • The increase in the Total Anti-oxidant levels was occurring in all patients of OPC poisoning , without any co-relation to the Peradeniya Organophosphorus Poisoning scale (POP). • The increase in Super oxide dismutase (SOD), Catalase, Malonyl dialdehyde (MDA), Glutathione Reductase, Glutathione transferase was occurring in all patients of OPC poisoning , without any corelation to the Peradeniya organophosphorus scale (POP).
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Serum Antioxidant Levels ; Clinical Manifestation ; Patients ; Organophosphorus Poisoning. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 28 Mar 2018 05:24 |
| Last Modified: | 31 Mar 2018 02:12 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/6686 |
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