Vijayasekaran, B (2008) Highly Sensitive C - Reactive Protein in the Patients with Unstable Angina and Its Prognostic Implications. Masters thesis, Madras Medical College, Chennai.
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Abstract
SUMMARY: hs_CRP estimation was done for 75 patients of Unstable Angina admitted in the medical ward of Institute Of Internal Medicine ,Madras Medical College Hospital following observation was made. • hs_CRP level in unstable Angina patients strongly correlates with number, duration and severity of Anginal episodes. • hs-CRP level strongly correlates with development of other complications such as development of heart failure, arrhythmias, left ventricular dysfunction. • hs_CRP level is increased in smoker, obesity, diabetes, hypertension, family history, post meno pausal women comparing to those without these risk factors. • hs_CRP level also increasing with advancing age. • hs_CRP level progressively increased in patients from IB to IIIB in Braunwald classification. CONCLUSION: Our understanding of atherosclerosis has evolved beyond the view that these lesions consist of a lifeless collection of lipid debris. Current evidence supports a central role for inflammation in all phases of the atherosclerotic process. Substantial biological data implicate inflammatory pathways in early atherogenesis, in the progression of lesions, and finally in the thrombotic complications of this disease. Clinical studies affirm correlation of hs_CRP is the novel and evolving biomarker of inflammation with propensity to develop ischemic events and with prognosis after ACS. Intralesional or extralesional inflammation may hasten atheroma evolution and precipitate acute events. Hs_CRP elicited by inflammation may not only mark increased risk for vascular events, but in some cases may contribute to their pathogenesis. This new insight into the role of inflammation in the pathobiology of atherosclerosis has initiated important new areas of direct clinical relevance. We can use hs_CRP today for risk stratification. Based on various studies, increased hs_CRP levels inpatients with high risk cardiovascular disease without documented CAD warrant treatment with statin even if LDL-C levels are within target range. Patients with documented CAD and high hs-hs_CRP levels should be followed, and there risk factors should be managed aggressively. Finally, the quest to identify proximal stimuli for inflammation, as one pathogenic process in atherogenesis or trigger to lesion complication, may yield novel therapeutic targets in years to come.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Highly Sensitive C - Reactive Protein ; Patients ; Unstable Angina ; Prognostic Implications. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 28 Mar 2018 04:10 |
| Last Modified: | 30 Mar 2018 18:00 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/6675 |
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