Serum Uric Acid in Acute Ischemic Stroke

Aarthi Priya, T (2008) Serum Uric Acid in Acute Ischemic Stroke. Masters thesis, Madras Medical College, Chennai.


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PURPOSE: To estimate the level of serum uric acid in patients with acute ischemic stroke, to find out its association with diabetes and hypertension, to correlate with age and gender and to study its significance in the out come of the stroke patients. METHODS: A cross section study was designed after institutional ethical clearance to screen acute ischemic stroke patients admitted to the hospital within 48 hours of stroke who satisfied a rigid inclusion and exclusion criteria. Another 40 members with similar variables without stroke were taken as control. The serum uric acid level was measured by uricase method. The outcome in the stroke patients was analysed at the end of 2 weeks while in hospital. The data were entered in microsoft excel spread sheet and analysed statistically. RESULTS: There were 102 stroke patients. Among them there were 66 males and 36 females. Their age varied from 30 to 70 years and the mean age was 56.72 years. The uric acid level among the stroke cases varied from 4.12 to 7.2 mg/dL and the mean serum uric acid level was 5.66 mg/dL. It was elevated significantly than the control group (P< 0.001). Stroke patients with diabetics and hypertension had elevated serum uric acid level than the counter parts in the control and the difference was significant statistically (P<0.001). Those stroke cases with elevated uric acid had poor outcome and statistically was significant (P < 0.001). CONCLUSION: Serum uric acid level was increased in stroke patients and was independent of age and gender. Uric acid level among stroke cases was independent of their diabetic and hypertensive status. All the stroke cases who had poor outcome were found to have elevated uric acid level which may be a response to oxidative stress and hence it can be considered as biochemical marker in stroke patients.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Serum Uric Acid ; Acute Ischemic Stroke.
Subjects: MEDICAL > General Medicine
Depositing User: Subramani R
Date Deposited: 28 Mar 2018 03:52
Last Modified: 30 Mar 2018 16:35

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