Formulation and Evaluation of Herbal Skin Cream for Wound Healing

Jamshiya, Shamsu (2017) Formulation and Evaluation of Herbal Skin Cream for Wound Healing. Masters thesis, R.V.S College of Pharmaceutical Sciences, Coimbatore.

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Abstract

INTRODUCTION: Creams are the semisolid dosage forms and intended for topical application to the skin, placed on the surface of eye, or used nasally, vaginally or rectally for therapeutic or protective action or cosmetic function. These preparations are used for the localized effects produced at the site of their application by drug penetration in to the underlying layer of skin or mucous membrane. These products are designed to deliver drug into the skin in treating dermal disorders, with the skin as the target organ Creams are semi-solid emulsions of oil and water. They are divided into two types: oilin- water (O/W) creams which are composed of small droplets of oil dispersed in a continuous phase, and water-in-oil (W/O) creams which are composed of small droplets of water dispersed in a continuous oily phase. Oil-in-water creams are more comfortable and cosmetically acceptable as they are less greasy and more easily washed off using water. Water-in-oil creams are more difficult to handle but many drugs which are incorporated into creams are hydrophobic and will be released more readily from a water-in-oil cream than an oil-in-water cream. Water-in-oil creams are also more moisturising as they provide an oily barrier which reduces water loss from the stratum corneum, the outermost layer of the skin. AIM AND OBJECTIVE: Natural products from plants are rich sources used for treating a number of diseases. Most of the herbal drugs are a mixture of a number of plant ingredients. Their synergistic effect increases the efficacy of the drug in curing the diseases. In this modern era, the knowledge and experience of usage of herbs are being blend with advanced formulation technology to develop a safe and elegant herbal product, which has wider range of people acceptability. Formulation of medicinal plant in the form of a cream will be made by mixing of plant extracts in different proportions and tested for wound healing activity. Methanolic extracts of plants such as Azadiractaindica (leaf),Samaderaindica (leaf),Curcuma longa (rhizome),Glycyrrhizagalbraith (root), Aloe vera (whole plant) are used for formulation of herbal skin cream for wound healing .Then the formulated skin cream is evaluated for parameters like physical properties, pH , viscosity, spreadability and stability of the formulated cream. OBJECTIVE OF THE STUDY: The purpose of the present investigation is to formulate and evaluate a herbal skin cream for wound healing. Herbal plants likeAzadiractaindica ,Samaderaindica,Curcuma longa ,Glycyrrhizagalbraith, Aloe vera are used for formulation of herbal skin cream for wound healing .Then the formulated skin is evaluated for parameters like physical properties, pH , viscosity, spreadability and stability of the formulated cream. The excipient concentrations are varied in order to find out the best formulation with better spreadability, viscosity ,stabilityetc. SUMMARY: The objective of the present work was to formulate and evaluate a skin cream for wound healing. Although various types of cream is considered for wound healing but these are still appears to be limited in rate of tissue regeneration. Plants are more potent healers because they promote the repair mechanism in the natural way.In this modern era, the knowledge and experience of usage of herbs are being blend with advanced cosmetic technology to develop a safe and effective product. In the present study, skin cream was prepared using herbal plants such as Azadiractaindica ,Samaderaindica, Curcuma longa , Glycyrrhizagalbraith and Aloe vera .Initially, the research work started with a wide and thorough literature survey .Various formulations were prepared by varying the amount of excipients such as stearic acid, bees wax, stearyl alcohol, tween-80, methyl paraben , sorbitol solution , potassium hydroxide ,deionised water ect. Formulation of Herbal Skin Cream for wound healing was successfully developed that met the relevant pharmaceutical characteristics. The prepared formulations are then evaluated for parameters like physical properties, pH , viscosity, spreadability and stability of the formulated cream. The prepared formulations showed good spreadability, no evidence of phase separation and good consistency during the study period. Stability parameters like visual appearance, nature, viscosity and pH of the formulations showed that there was no significant variation during the study period. The prepared formulations showed proper pH range that is approximately pH 6; it confirms the compatibility of the formulations with skin secretions. The creams were found to be stable during stability study according to ICH guidelines (40 ± 2 °C/ 75 ± 5 % RH) for 3 months. From the present study it can be concluded that it is possible to develop creams containing herbal extracts and can be used as a barrier to protect skin. CONCLUSION: Formulation of Herbal Skin Cream for wound healing was successfully developed that met the relevant pharmaceutical characteristics. The prepared formulations showed good spreadability, no evidence of phase separation and good consistency during the study period. Stability parameters like visual appearance, nature, viscosity and pH of the formulations showed that there was no significant variation during the study period. The prepared formulations showed proper pH range that is approximately pH 6; it confirms the compatibility of the formulations with skin secretions. The creams were found to be stable during stability study according to ICH guidelines (40 ± 2 °C/ 75 ± 5 % RH) for 3 months. From the present study it can be concluded that it is possible to develop creams containing herbal extracts and can be used as the provision of a barrier to protect skin.Plants are more potent healers because they promote the repair mechanism in the natural way. The wound healing property of the formulated herbal skin cream has yet to be experimented and will be done in future.

Item Type: Thesis (Masters)
Additional Information: Reg NO.261510752
Uncontrolled Keywords: Formulation ; Evaluation ; Herbal Skin Cream ; Wound Healing
Subjects: PHARMACY > Pharmaceutics
Depositing User: Ravindran C
Date Deposited: 26 Mar 2018 07:36
Last Modified: 26 Mar 2018 07:36
URI: http://repository-tnmgrmu.ac.in/id/eprint/6609

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