Kiruthika, S (2017) Design and Development of Pharmacosomes for Oral Drug Delivery of Losartan. Masters thesis, KMCH College of Pharmacy, Coimbatore.
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Abstract
INTRODUCTION: Pharmacosomes bear unique advantages over liposome and noisome vesicles and serve as an alternative to conventional vesicles. They are the colloidal dispersions of drugs covalently bound to lipids. Depending upon the chemical structure of the drug-lipid complex they may exist as ultrafine vesicular, micellar, or hexagonal aggregates. As the system is formed by linking a drug (pharmakon) to a carrier (soma), they are termed as “pharmacosomes”. They serve as an effective tool to achieve desire therapeutic goals in terms of drug targeting and controlled release of drug. The criterion for the development of the vesicular pharmacosome is dependent on surface and bulk interactions of lipids.8 Any drug possessing an active hydrogen atom can be esterified into the lipid, with or without spacer chain that strongly result in the formation of an amphiphilic compound, which facilitates better penetration in to the target site. The prodrug conjoins with hydrophilic and lipophilic properties, thus acquires amphiphilic characters. The amphiphilic characters help pharmacosomes to reduce the interfacial tension and at higher contraction exhibits mesomorphic behavior. This decrease in the interfacial tension leads to an increase in the contact area, thereby increasing the bioavailability of drug. AIM OF STUDY: The aim of the study is to prepare pharmacosomes containing Losartan using different concentrations of soya lecithin by solvent evaporation technique in order to achieve a prolonged release of drug and also to improve the bioavailability of the drug. OBJECTIVES OF STUDY : The objectives of the study are: 1. To formulate pharmacosomes of losartan by solvent evaporation method. 2. To characterize the prepared pharmacosomes by different methods including preformulation studies, drug content determination and solubility studies. 3. To prepare capsules containing the pharmacosomes. 4. To carry out the quality control tests for capsules. 5. To perform the vesicle shape determination, X-ray powder diffraction analysis (XRD) and drug release kinetic data analysis of the optimized formulation. 6. To carry out the stability studies of the optimized formulation of pharmacosome as per ICH guidelines. CONCLUSION: In the present study the Losartan- phospholipid complexes (pharmacosomes) were prepared by a simple and reproducible method. The physicochemical investigations confirmed that Losartan formed a complex with phospholipids with better solubility and dissolution profile. The phospholipid complex of Losartan may be of potential use for improving bioavailability. As the phospholipid complex have also been reported to reduce the GI toxicity of the drugs, the phospholipid complex of Losartan may also be useful or minimizing the GI toxicity of Losartan. The pharmacosomes may be developed for other drugs with poor bioavailability and GI side effects. Thus, the formulated pharmacosomes seem to be potential candidate as an oral controlled drug delivery system in this era of novel and controlled drug delivery systems. The developed formulations are expected to improve the patient compliance and from better dosage regimen.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg.No.261510902 |
| Uncontrolled Keywords: | Pharmacosomes ; Oral Drug Delivery ; Losartan |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 26 Mar 2018 06:09 |
| Last Modified: | 26 Mar 2018 06:09 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/6603 |
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