Rajakumar, C R (2013) A Study on Left Ventricular Diastolic Function assesed by Echo in Metabolic Syndrome. Masters thesis, Stanley Medical College, Chennai.
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Abstract
INTRODUCTION: Metabolic syndrome Characterised by four clinical elements: these are Atherogenic dyslipidemia, insulin resistance (IR), central Obesity, and high blood pressure. The metabolic syndrome includes group of cardiac risk factors that act simultaneously. The persons with this syndrome who are worst prognosis cardiovascular events This is a is a group of components distressing about 20- 25% of adults population in developed countries. In India, prevalence is about 21% to 25% in adults. elevated BP, Hyperglycemia and central obesity harmfully affected in heart both physiologically and pathologically. This disease and its components, such as hyper glycemia, raised BP, Lipid profile abnomalities and central obesity are progressively more common among our people due to inactive life style. These people most commonly manifested as Heart failure but patients had normal ejection fraction (HFNEF). Persons with the metabolic syndrome have a high incidence of heart failure HF. patients with metabolic syndrome they are greater threat of cardiac events than not associated this disease. This study aimed to evaluate the association between Left ventricular diastolic dysfunction and Metabolic syndrome. So far there is minimal literature in our institute regarding the study of diastolic dysfunction in subjects with metabolic syndrome. AIMS AND OBJECTIVES: 1. To assess left ventricular function in metabolic syndrome. 2. To grade the diastolic dysfunction and clinical outcome. MATERIALS AND METHODS: Study Site: Department of General Medicine, Government Stanley Medical College and Hospital, Chennai. Collaborating Departments: Department of Cardiology and Department of Medical Biochemistry. Study Design: Longitudinal study. Study Period: June 2012 to November 2012. Sample Size: Using the above mentioned criteria 50 subjects were recruited. Sampling Method: Convenience sampling method was adopted. Selection of Study Population: Inclusion Criteria: Patients meeting criteria for metabolic syndrome without co morbid illness Exclusion Criteria: • Cushing syndrome. • Hypothyroidism. • Anasarca. • Known heart disease patients. • Gout. • Polycystic ovarian disease. STATISTICAL ANALYSIS: Statistical analysis was done using • Percentages, • Mean values, • Standard deviation, • Standard error, • Chi square test, • T-test unpaired, Level of significance used is 0.05 for the corresponding degree of freedom to draw the inference. A p value <0.05 was considered statistically significant. CONCLUSION: • Left ventricular diastolic dysfunction was observed in 52% of total subjects and 48% of total subjects have normal left ventricular function. 36% impaired relaxation cases and 16% pseudo normal cases contributed to th 52% prevalence of LVDD. • Recognition of pseudonormal pattern of utmost importance. It is an intermediary stage between mild impaired relaxation state and advanced restrictive filling stage. • LVDD had no correlation with blood pressure, fasting blood sugar, waist measurement, triglycerides and high density lipoproteins level. • LVDD is the earliest manifestation of metabolic disease related cardiomyopathy. Hence detecting it early will prevent disease progression to symptomatic cardiac failure and bring down the disease burden. • The clinical significance of the findings in terms of prognosis and treatment needs to be determined. • This study is a hypothesis generating study. • Hence results from our study needs to be reinvestigated using robust research designs like cohort studies. • Conventional echocardiography is a simple economical test for detecting LVDD in metabolic syndrome patients who are asymptomatic. • ECHO diagnostic factors like E/A ratio, DT and IVRT should be should be studied further and developed into accurate cost effective screening tools for screening asymptomatic LVDD.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Left Ventricular Diastolic Function ; Echo ; Metabolic Syndrome. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 25 Mar 2018 08:36 |
| Last Modified: | 28 Mar 2018 02:48 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/6581 |
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