Arunkumar, G (2013) A Study on Clinical Profile of Rodenticide Poisoning at Government Stanley Hospital, Chennai - 600 001. Masters thesis, Stanley Medical College, Chennai.
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Abstract
INTRODUCTION: Rodenticide toxicity is one of the common modes of poisoning encountered in our part of the country. It is cheap and easily available in the market, in various forms such as powder, cake, paste etc. The rodenticides manufactured by standard companies has a fixed concentration of chemical, whereas the locally made rodenticides do not have such fixed concentration. Rodenticide toxicity can range from asymptomatic presentation to life threatening complications and death, based on the amount and type of rodenticide ingested. As compared to older and conventional rodenticides, the newer and modern rodenticides are more toxic to human beings. There are case studies and case reports that highlight the toxic effects of various types of rodenticides in human beings. This study is about the clinical profile and the outcome of patients with rodenticide poisoning. AIMS AND OBJECTIVES: 1. To study the clinical profile of patients admitted with rodenticide poisoning at IMCU, Govt. Stanley hospital, Chennai. 2. To assess the morbidity, mortality and clinical outcome of those patients. MATERIALS AND METHODS: Place of Study: This study has been carried out at the toxicology unit of Intensive Medical Care Unit and Medical wards of Govt. Stanley hospital, Chennai. Study Period: One year (From November 2011 to November 2012). Study Design: This is a Retrospective and Prospective observational study. Inclusion Criteria: 1. Any patient admitted with rodenticide intake, 2. Age of the patients > 13 years. Exclusion Criteria: 1. Mixed poisons, 2. Chronic liver disease, 3. Alcohol intake within 24 hours before admission, 4. Patients on drugs like anticoagulants, antiplatelets, 5. Patients with bleeding disorders, 6. Acute diarrhoeal disease, 7. Patients with known coronary artery disease RESULTS: The total number of patients included in the study was 421. But only 303 patient’s data was finally included for the analysis. The remaining 118 patients did not give consent, absconded or were discharged prematurely before the completion of investigations and were excluded from the study. The remaining 303 patients’ data were taken for final analysis. CONCLUSION: Rodenticide poisoning, though commonly remarked as ‘rat never dies’; can be fatal to humans when the specific ingredient is consumed in a lethal dose. Although there are ample studies about individual types of rodenticide, to our best of knowledge, we could not find any other study in the literature that compares the various types. Having said that, we must say the comparative study has yielded few striking facts. • Zinc phosphide is the most prevalent poison in our study, but their mortality and morbidity rate is very low • Super warfarin poisoning, the second common rodenticide in ourstudy, produced significant derangement in coagulation parameters, but failed to manifest clinically. (In short, it is rather benign) • Yellow phosphorous, although leastcommon in our study, had a significant impact on the patient’s outcome. The mortality rate is a whopping 50% among the consumed. Rodenticide poisoning, though encountered every day, had so many nuances and intricacies, which became apparent to us after analysing their clinical profile. Indeed, it is a very satisfying experience in a common poison!
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Rodenticide Poisoning ; Government Stanley Hospital ; Chennai ; Clinical Profile. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 25 Mar 2018 06:18 |
| Last Modified: | 28 Mar 2018 01:30 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/6575 |
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