Sathis Kumar, S (2009) A Study of Clinical Profile in Mitral Valve Prolapse Syndrome: A Series of 100 cases. Masters thesis, Stanley Medical College, Chennai.
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Abstract
INTRODUCTION: The Mitral Valve Prolapse syndrome has been recognized as one of the most prevalent cardiac valvular abnormalities affecting 5 – 10% of the population. In majority of the patients with Mitral Valve Prolapse, the cause is unknown. The overwhelming majority of the patients are asymptomatic. The clinical presentation of Mitral Valve Prolapse is also diverse. They present with a variety of symptoms such as fatigability, palpitation, postural giddiness and neuro psychiatric symptoms of autonomic dysfunction. Patients with Mitral Valve Prolapse may have a variety of cardiac and non cardiac abnormalities in addition to valvular lesion with its midsystolic click and murmur. This includes skeletal abnormalities like scoliosis, straight back syndrome, Pectus excavatum and asthenic build, abnormal cardiovascular and electrocardiographic responses to exercise, ST-T changes in resting ECG and a variety of Atrial and ventricular arrhythmias. Wooley reported clinical similarities between Mitral Valve Prolapse and Da Costa syndrome, vasoregulatory asthenia described by Holmgren et al and hyperkinetic heart syndrome reported by Gorlin. The presence of chest pain, ST-T abnormalities and arrhythmias in the absence of hemodynamically significant valvular, myocardial or coronary arterial disease suggests the possibility of a disorder involving autonomic system. Greater attention and enthusiasm on this condition has been developed because of high prevalence of the condition and increased risk of sudden death. Since special therapeutic, prognostic and genetic factors must be considered in Mitral Valve Prolapse syndrome, precise identification of the condition is essential. AIM OF THE STUDY: The Aim of this study is to study the clinical profile of Mitral Valve Prolapse Syndrome and investigating the existence of Autonomic Dysfunction in the subjects studied through bedside tests. MATERIALS AND METHODS: Place and Period: This study was done in Govt. Stanley Hospital. Study was done for a period of 1 year, from September 2007 to august 2008. 100 cases were taken into the study. Inclusion Criteria: All patients with: • Age 14 - 43. • Mid systolic click. • Late systolic murmur. • Or both. Exclusion Criteria: • Hypertension. • Diabetes Mellitus. • Coronary Artery Disease. • Congestive Cardiac Failure. • Those on cardio active or neuro active drugs. • Systemic illness. CONCLUSION: The Present Study Indicates: 1. Out of 100 cases, 56 cases were females and 44 cases were males. So the disease is common in females. 2. The most common symptom is Chest discomfort followed by Palpitation. 3. The most common sign is click followed by Murmur. 4. The most common involved valve is Posterior Mitral Leaflet. 5. Isolated Mitral Valve Prolapse is the most common presentation and only rarely associated with others like Atrial Septal Defect. 6. The most common ECG abnormality was ST – T changes. 7. Marfanoid Habitus was present in 56 patients. 8. Autonomic Dysfunction revealed by bedside tests was found in 16 patients. Of which Immediate Heart Rate response to Standing 30:15 ratio was the most common abnormality.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Mitral Valve Prolapse Syndrome ; Clinical Profile ; Series of 100 cases. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 23 Mar 2018 16:54 |
| Last Modified: | 24 Mar 2018 09:10 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/6513 |
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