Naseem, A K (2017) Development, Characterization and Statistical Optimization of Almotriptan Malate Loaded Transdermal Patches for the Treatment of Migraine. Masters thesis, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore.
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Abstract
INTRODUCTION: The development of a new drug molecule is a time consuming procedure and requires approximately 125 million dollars. This is beyond the scope of pharmaceutical companies in developing countries like India. But it is possible to give a new life to the existing molecules by formulating them in the form of novel drug delivery systems. Therefore, in recent years, considerable attention has been focused on the development of new drug delivery systems. The therapeutic efficacy and safety of the drugs administered by convention methods can be improved by more precise spatial and temporal placement within the body, thereby reducing both the size and number of doses through a controlled drug delivery. RESEARCH OBJECTIVE: Almotriptan Malate is a highly selective serotonin 5-HT1B/1D receptor agonist. According to the FDA Clinical Review, Almotriptan Malate is effective in the acute treatment of moderate to severe migraine attacks in adult and adolescent patients with a history of migraine with or without aura. Several studies have reported that Almotriptan Malate has the best sustained pain-free rate and the lowest adverse events rate of all the triptans. It is consistently one of the preferred triptans in multi attribute decision-making analyses. 1. To design the formula for transdermal patches, preliminary trials were conducted with different concentration of different polymer combination. 2. To select the best polymer combination. 3. To carry out the compatibility studies of drug and selected polymer combinations. 4. To incorporate selected model drug candidates in the formula and prepare patches. 5. To characterize the formulated patches for the physico-mechanical characteristics. 6. To carry out the in vitro drug release studies of the formulated patches through dialysis membrane using Franz diffusion cell. 7. To design the optimized formulation by simple 22 factorial designs by using statistical software. 8. To check the stability of the formulated patches. 9. To evaluate the drug release kinetics for the best formulation among the other patches. CONCLUSION: The present investigation, it may be concluded that such matrix type transdermal patches of Almotriptan Malate may provide sustained transdermal delivery for prolonged periods in the management of migraine, which can be a good way to bypass the extensive hepatic first pass metabolism. The result of the study showed the feasibility of formulating rate-controlled transdermal films of Almotriptan Malate for effective control and prophylaxis of migraine. Further invivo investigations are required to correlate in-vitro permeation studies for the development of suitable transdermal system of Almotriptan Malate.
| Item Type: | Thesis (Masters) |
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| Additional Information: | REG.No.261510154 |
| Uncontrolled Keywords: | Characterization ; Statistical Optimization ; Almotriptan Malate Loaded Transdermal Patches ; Treatment ; Migraine |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 23 Mar 2018 07:01 |
| Last Modified: | 23 Mar 2018 07:01 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/6473 |
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