Recent Trends in Lung Cancer

Prabhakaran, R (2007) Recent Trends in Lung Cancer. Masters thesis, Madras Medical College, Chennai.


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INTRODUCTION : Lung cancer is presently one of the most common malignancies through out the world. There has been an increase in incidence in the last 50 years. All histological types of lung cancer increasing incidence but different degrees. During a period of refinement of thoracic departmental lung cancer tumour registry it became apparent that along with an increasing incidence of lung cancer among women there was also an increasing prevalence of adenocarcinoma among lung cancer patients of both sex. Primary studies in India show an increasing trend in lung cancer compared to a quarter of century ago. Studies from India have emphasized significant epidemiological and cell type difference that exist in the country compared to that reported in the west. The increase in incidence of bronchogenic carcinoma is not only due to better diagnostic facilities like flexible fibreoptic bronchoscopy but also other factors like increase in number of smokers, increasing environmental pollution and increase in number of people living in higher age groups. AIM OF STUDY : An open prospective study was undertaken to study the recent profile of Lung cancer. MATERIALS AND METHODS : An open prospective study of patients who attended THORACIC Medicine Department at Government General Hospital Chennai, and Institute of Throracic Medicine, Chetpet, with clinical and/or radiological suspicion of lung cancer was studied over a period of 12 months between January 2005 and 2006. The study protocol included a detailed history regarding the onset and progress of the disease, smoking habits and other associated risk factors if any. Inclusion criteria : All the patients who had clinical features and radiological abnormalities suggestive of lung cancer have been included. Exclusion criteria: Among the patients included in this study those did not have histopathological proof have been excluded and the remaining were analysed. The complaints which were evaluated in detail included cough, sputum, chest pain, dyspnea, fever, weight loss, hoarseness of voice, dysphagia and symptoms suggestive of SVC obsturuction, paraneoplastic syndromes and systematic metastasis. A detailed general and systematic examination was preformed. All patients were subjected to baseline blood investigations, chest x ray PA and lateral view, ultrasound abdomen and chest. Computerized Tomography of chest was done to characterize the lesion further and t help to arrive at tissue diagnosis. FOB was done in some patients to detect and aid in getting at histopathological diagnosis. RESULTS : 123 Patients were included in the study. Pathological diagnosis was possible in patients. Eleven patients in whom cell type diagnosis was not possible the procedure done for pathological diagnosis were inconclusive. The eleven patients had x-ray features suggestive of mass lesion along with computerized tomography of the chest confirming the same. In these eleven patients malignant cells could be identified but the exact cell type diagnosis was not possible. CONCLUSIONS : 1. The most common pathological cell type in this study was squamous cell carcinoma followed by adenocarcinoma. 2. Male sex, age >50 years, history of tobacco smoking were still a risk factor for Lung cancer. 3. Male, female ratio 6.6:1 4. Adenocarcinoma was found to be the commonest cell type of cancer among females and non smokers. 5. Clubbing was most commonly associated with squamous cell carcinoma. 6. most common radiological presentation was mass lesion. 7. Fiberoptic bronchoscope biopsy and brushing, computerized tomography/ ultra sonogram core needle biopsy were valuable tools to get at tissue diagnosis in 80% of patients.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Lung Cancer ; Recent Trends.
Subjects: MEDICAL > Tuberculosis and Respiratory Medicine
Depositing User: Kambaraman B
Date Deposited: 29 Jun 2017 09:52
Last Modified: 28 Feb 2018 15:55

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