A study of peripheral nervous system alterations in hypothyroid patients

Jeyabanu, M (2015) A study of peripheral nervous system alterations in hypothyroid patients. Masters thesis, PSG Institue of Medical Sciences and Research, Coimbatore.


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Hypothyroidism is an endocrine disorder of deficient thyroid hormone levels in the circulation. Thyroid hormones are essential for the normal functioning of the brain and nervous system. One of the manifestations of the hypothyroidism is the peripheral neuropathy. METHODS This cross sectional study includes 30 hypothyroid patients and 30 normal subjects between the age group of 20 to 60 years. The nerve conduction study was done using Recorders Medicare System (RMS) EMG EPM2K version-1. Three parameters (latency, amplitude and nerve conduction velocity) of motor and sensory component of three nerves (Median nerve, Ulnar nerve and Peroneal nerve) were compared between cases (Hypothyroidism) and controls (non hypothyroid). Statistical analysis was done by unpaired ‘t’ test and ANOVA with SPSS software for various analysis. RESULTS The nerve conduction velocity is reduced in right median, right and left ulnar and left common peroneal nerves. The latency is prolonged in the right and left ulnar nerve as well as in the peroneal (both right and left) nerve. The amplitude of the nerve conduction action potential of the all the nerves is not significantly reduced. The sensory nerve conduction velocity of the sural nerve is reduced in our present study. There is no correlation between the nerve conduction abnormalities and the age and duration of the disease in hypothyroid patients. CONCLUSION The prevalence of neuropathy in hypothyroid patients attending the PSG Institute of Medical Science and Research, Coimbatore is 56.66 %. In this study 36.66% hypothyroid patients (11) were found to be with carpal tunnel syndrome. The physiological parameters (age and duration of the disease) were not correlated with nerve conduction values. The median nerve was the most affected nerve in the upper limb and the sural nerve was the commonly affected nerve in the lower limb.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Hypothyrodism; Nerve Conduction Study
Subjects: MEDICAL > Physiology
Depositing User: Punitha K
Date Deposited: 22 Mar 2018 07:28
Last Modified: 22 Mar 2018 07:28
URI: http://repository-tnmgrmu.ac.in/id/eprint/6425

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