Histomorphological Profile of Endometrium in Perimenopausal Bleeding.

Johnsy Merla, J (2013) Histomorphological Profile of Endometrium in Perimenopausal Bleeding. Masters thesis, Tirunelveli Medical College, Tirunelveli.


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Perimenopausal Bleeding Is One Of The Commonest Conditions For Which Patients Seek Advice In The Gynaecological Outpatient Department. The Prevalence Increases With Age, Peaking Just Prior To Menopause. Because Most Cases Are Associated With Anovulatory Menstrual Cycles, Perimenopausal Women Are Particularly Vulnerable. Throughout The Perimenopausal Transition, There Is A Significant Incidence Of Dub Due To Anovulation1. Perimenopause Is The Period 2-8 Years Preceding The Menopause And 1 Year After Final Menses (Who).However A Better Definition Is The Phase Preceeding The Onset Of Menopause, Occurring Around The Age Of 40-50 Years (Beginning At Age 47.5, Lasting For 4 Years) During Which The Regular Menstrual Cycle Of A Woman Transitions To A Pattern Of Irregular Cycles.2 Perimenopausal Bleeding Refers To The Symptoms Of Excessive, Unexpected, Prolonged, Or Acyclic Bleeding, Regardless Of The Diagnosis Or Cause 3.With Medical Advancements And The Increasing Awareness About Gynaecological Problems, Most Women Gain Access To Most Of The Diagnostic And Therapeutic Modalities. Endometrial Biopsy Is Relatively Simple, Accurate And Inexpensive. The Only Disadvantage Of The Endometrial Biopsy Is That, It Is An Invasive Procedure. The Main Reason For Obtaining Endometrial Histology In Perimenopausal Patients With Bleeding Is To Exclude The Presence Of Endometrial Hyperplasia Or Carcinoma Of Endometrium4. Both Typical Hyperplasia And Atypical Hyperplasia May Regress Spontaneously Over Months Or Few Years. However, Atypical Hyperplasia Is A Precancerous Condition That May Progress To Malignancy And Best Treated By Surgery With Hysterectomy. Hyperplasia Without Atypia Regresses Spontaneously After D&C Or Progestin Treatment. In Patients With Atypical Hyperplasia, If Conserving The Uterus Is Considered, A Trial Of Hormonal Treatment May Be Given. Analysis Of Steroid Hormone Receptors Play An Important Role In Patients With Perimenopausal Bleeding To Predict The Response To Hormonal Therapy4. Currently, The Steroid Hormone Receptor Status Of Carcinoma Of The Endometrium Has Been Demonstrated To Be Prognostically Important. In This Study Of 200 Cases An Attempt Is Made To Evaluate The Histomorphological Profile Of Endometrium In Perimenopausal Bleeding, And The Immunohistochemical Expression Of Er And Pr In Endometrial Hyperplasias.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Histomorphological Profile ; Endometrium ; Perimenopausal Bleeding.
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 29 Jun 2017 10:32
Last Modified: 29 Jun 2017 10:32
URI: http://repository-tnmgrmu.ac.in/id/eprint/642

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