Akhil, S B (2017) A Pharmacological Evaluation for the Ethanolic Extract of Alpinia Calcarata Rhizome for it’s Anti - Asthmatic, Antioxidant and Anti - Inflammatory Activities. Masters thesis, Padmavathi College of Pharmacy & Research Institute, Dharmapuri.
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Abstract
INTRODUCTION:Medicinal plants such as Aloe, Tulsi, Neem, Turmeric and Ginger cure several common ailments. These are considered as home remedies in many parts of the country. It is known fact that lots of consumers are using Basil (Tulsi) for making medicines, black tea, in Pooja and other activities in their day to day life. In several parts of the world many herbs are used to honour their kings showing it as a symbol of luck. Now, after finding the role of herbs in medicine, lots of consumers started the plantation of tulsi and other medicinal plants in their home gardens. Medicinal plants are considered as a rich resources of ingredients which can be used in drug development either pharmacopoeial, non- pharmacopoeial or synthetic drugs. A part from that, these plants play a critical role in the development of human cultures around the whole world. Moreover, some plants are considered as important source of nutrition and as a result of that they are recommended for their therapeutic values. Some of these plants include ginger, green tea, walnuts, aloe, pepper and turmeric etc. Some plants and their derivatives are considered as important source for active ingredients which are used in aspirin and toothpaste etc. AIM & OBJECTIVES: In recent year there has been tremendous increase in demand for herbal drugs because of its safety, efficacy and better therapeutic results. Due to its economic pricing as compared to synthetic or allopathic drugs, which have several therapeutic compilations. Alpinia calcarata is also considered to be therapeutically important in traditional system of medicine. Aim of the study to evaluate the anti-asthmatic, antioxidant and anti-inflammatory activities of ethanolic extract of Alpinia calcarata rhizome. The objective study includes 1. To study the anti-asthmatic effect of ethanolic extract of Alpinia calcarata rhizomes. 2. To study the in vitro antioxidant activity of the ethanolic extract of Alpinia calcarata rhizomes. 3. To study the in vitro anti-inflammatory activity of the ethanolic extract of Alpinia calcarata rhizomes. SUMMARY: Herbal formulations used in the treatment of asthma include some anti-stress herbs to enable adoption to stress since excessive stress or nervous debility may aggravate symptoms of asthma. The normalization effect of an adaptogen can be observed in milk induced leukocytosis after administration of milk. Also eosinophil play a pivotal role in the pathogenesis of allergic disorders. The plant extract showed marked protection against eosinophil cell count, which is a hallmark of allergic asthma as compared to control group. The reduction in eosinophil count means inhibition in eosinophil cell recruitment and inhibition of interleukins such as IL-4, IL-5 and IL-13 which play important role in eosinophil cell count. So the milk induced leukocytosis and eosinophilic study revealed anti asthmatic property of the plant extract. Histamine contracts the tracheal-bronchial muscle of guinea pig, goat, horse, dog and man. Guinea pig trachea is used for the screening of anti-asthmatic activity. The H1 receptor after stimulation produces well-ordered dose related contraction of isolated guinea pig trachea. In current study Alpinia calcarata significantly inhibited histamine induced contraction of isolated guinea pig trachea preparation indicating its H1 receptor antagonist activity and supports anti asthmatic property of the plant. The antioxidant property was studied by hydrogen peroxide scavenging assay and reducing power assay. Hydrogen peroxide scavenging ability of ethanolic extract of Alpinia calcarata rhizomes revealed that the extract scavenge the hydrogen peroxide. However, the hydrogen peroxide scavenging ability was low comparing to standard (ascorbic acid). Reducing power of ethanolic extract of Alpinia calcarata rhizomes significantly increased with increasing concentration. The in vitro anti-inflammatory potential of ethanolic extract of Alpinia calcarata rhizomes had shown concentration dependent inhibition of protein denaturation, hypotonicity induced haemolysis of rabbit red blood cell membrane stabilization. CONCLUSION : The result of the investigation showed that the ethanolic extract of Alpinia calcarata rhizomes possess anti asthmatic activity. The antioxidant and antiinflammatory property of the plant also supports its anti-asthmatic property. Drugs effective in asthma are mostly steroidal in nature. Phytochemical analysis showed presence of flavonoid and steroids. The anti-asthmatic property showed by the plant may be because of these chemical moieties. The results obtained in the study supports the traditional and also demands further research and to isolate and characterize active principles responsible for anti-asthmatic activity.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg.No: 261525752 |
| Uncontrolled Keywords: | Pharmacological Evaluation ; Ethanolic Extract ; Alpinia Calcarata Rhizome ; Anti - Asthmatic ; Antioxidant ; Anti - Inflammatory Activities |
| Subjects: | PHARMACY > Pharmacology |
| Depositing User: | Ravindran C |
| Date Deposited: | 21 Mar 2018 09:06 |
| Last Modified: | 21 Mar 2018 09:06 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/6415 |
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